Document Detail


An apparent unidirectional influx constant for manganese as a measure of myocardial calcium channel activity.
MedLine Citation:
PMID:  17024667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To develop an in vivo MR method for evaluation of myocardial calcium channel activity through quantification of apparent unidirectional manganese influx constants following manganese dipyridoxyl-diphosphate (MnDPDP) infusions. MATERIALS AND METHODS: A total of 10 healthy volunteers were divided in two groups, and received 5 micromol of MnDPDP per kg of body weight intravenously in a 1.5 Tesla scanner over five or 30 minutes, respectively. A fast inversion recovery gradient echo sequence was used to estimate pre- and postcontrast R1 values and to measure signal changes following infusions. By assuming equal longitudinal relaxivity (r1) of the contrast in all tissue compartments, signal changes in blood and myocardial tissue yielded temporal input and tissue contrast concentrations respectively. Through a two-tissue compartment model, apparent unidirectional influx constants (Ki) for myocardial manganese accumulation were estimated. RESULTS: Consistent values for Ki in left ventricular wall were found, with a mean value of 5.96 mL/100 g/minute (SD=0.49; N=10). No statistical significant differences in Ki were found between the two infusion groups. CONCLUSION: Since unidirectional manganese accumulation depends upon intact myocyte membranes with functioning calcium channels, the use of unidirectional manganese influx rates may be a valuable research tool for in vivo studies of myocyte functioning in myocardial disease.
Authors:
Arne Skjold; Anders Kristoffersen; Torgil R Vangberg; Olav Haraldseth; Per Jynge; Henrik B W Larsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  24     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1047-55     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2006 Wiley-Liss, Inc.
Affiliation:
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), and Department of Medical Imaging, St. Olavs Hospital, Trondheim, Norway. Arne.Skjold@stolav.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcium Channels / metabolism*
Contrast Media / pharmacokinetics
Echo-Planar Imaging / methods*
Edetic Acid / analogs & derivatives*,  diagnostic use,  pharmacokinetics
Female
Humans
Image Interpretation, Computer-Assisted / methods*
Ion Channel Gating / physiology*
Kinetics
Male
Metabolic Clearance Rate
Myocardium / metabolism*
Pyridoxal Phosphate / analogs & derivatives*,  diagnostic use,  pharmacokinetics
Radiopharmaceuticals / diagnostic use,  pharmacokinetics
Reference Values
Chemical
Reg. No./Substance:
0/Calcium Channels; 0/Contrast Media; 0/Radiopharmaceuticals; 119797-12-5/N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid; 54-47-7/Pyridoxal Phosphate; 60-00-4/Edetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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