Document Detail

The apparent absorptions of isoflavone glucosides and aglucons are similar in women and are increased by rapid gut transit time and low fecal isoflavone degradation.
MedLine Citation:
PMID:  15465743     Owner:  NLM     Status:  MEDLINE    
We hypothesized that there would be no difference in apparent absorption, as assessed by urinary excretion, between isoflavone sources rich in glucosides or aglucons and that subjects with rapid gut transit time (GTT) and low fecal isoflavone degradation phenotype would absorb more isoflavones. Women (n = 13) with a fecal daidzein degradation rate constant, D(k) > 0.30 h(-1) (high degraders) and GTT of 106 +/- 11 h and women (n = 12) with D(k) < 0.20 h(-1) (low degraders) and GTT of 71 +/- 12 h were randomly assigned to 3 treatments: soygerm (1.1 micromol/kg body weight, n = 5 high degraders, 4 low degraders), fermented soygerm (3.3 micromol/kg, n = 4 high and 4 low degraders) or Novasoy isoflavone extract (1.5 micromol/kg, n = 4 high and 4 low degraders) for 7 d. By HPLC analysis, 24-h urinary excretion of soygerm was greater than Novasoy (51 +/- 6 vs. 26 +/- 6% of ingested dose, P < 0.05). Women of the low daidzein degradation phenotype had greater urinary isoflavone excretion than did women of the high daidzein degradation phenotype (51.6 +/- 4.8 vs. 33.8 +/- 4.7%, P < 0.05, mean of d1 and 7). The plasma total isoflavone level (estimated as a percentage of the ingested amount, mean of d 1 and 7) differed between women who consumed fermented soygerm and soygerm 3 h after feeding (1.8 +/- 0.3 vs. 0.5 +/- 0.3%, P < 0.05). Urinary excretions of aglucons and glucosides did not differ. The study confirmed that rapid GTT and low fecal isoflavone degradation rate increased the apparent absorption of isoflavones.
Yan Zheng; Sun-Ok Lee; Marian A Verbruggen; Patricia A Murphy; Suzanne Hendrich
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  134     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2534-9     Citation Subset:  IM    
Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA.
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MeSH Terms
Administration, Oral
Biological Availability
Estrogens, Non-Steroidal
Gastrointestinal Transit
Intestinal Absorption
Isoflavones / blood,  genetics,  metabolism,  pharmacokinetics*
Reg. No./Substance:
0/Estrogens, Non-Steroidal; 0/Isoflavones; 486-66-8/daidzein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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