Document Detail


The apolipoprotein CII gene: subchromosomal localisation and linkage to the myotonic dystrophy locus.
MedLine Citation:
PMID:  2991117     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human apolipoprotein CII gene probe detects a restriction fragment length polymorphism located on chromosome 19. We have investigated the linkage of this polymorphism to the myotonic dystrophy locus in families. The two loci are closely linked with a maximum Lod score of 7.877 at 4% recombination. The close linkage and informativeness of the APOC2 polymorphism suggest that this probe may be of use for presymptomatic diagnosis of the myotonic dystrophy gene. The APOC2 gene was localised to the region 19p13-19q13 using somatic cell hybrids, providing further evidence that the myotonic dystrophy locus is situated in the central region of chromosome 19.
Authors:
D J Shaw; A L Meredith; M Sarfarazi; S M Huson; J D Brook; O Myklebost; P S Harper
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  70     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1985  
Date Detail:
Created Date:  1985-09-06     Completed Date:  1985-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  271-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoprotein C-II
Apolipoproteins C / genetics*
Chromosome Mapping*
Chromosomes, Human, 19-20*
DNA Restriction Enzymes
Female
Genetic Markers
Humans
Hybrid Cells
Lod Score
Male
Myotonic Dystrophy / genetics*
Polymorphism, Genetic
Chemical
Reg. No./Substance:
0/Apolipoprotein C-II; 0/Apolipoproteins C; 0/Genetic Markers; EC 3.1.21.-/DNA Restriction Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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