| The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis. | |
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MedLine Citation:
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PMID: 21776394 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background. Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis. Methods. A cross-sectional study was conducted with 81 subjects, aged 56-80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and carotid atherosclerosis was determined by ultrasound examination. VLDL particles, Sf 20-400, were isolated and their lipid composition and apoC-I content determined. Results. The carotid plaque area increased linearly with the number of apoC-I molecules per VLDL particles (P = 0.048) under fasting conditions. Fasting triglycerides increased across tertiles of apoC-I per VLDL particle in analyses adjusted for apoC-II and -C-III, apoE genotype and traditional cardiovascular risk factors (P = 0.011). The relation between apoC-I in VLDL and serum triglycerides was conveyed by triglyceride enrichment of VLDL particles (P for trend <0.001. The amount of apoC-I molecules per VLDL was correlated with the total (r = 0.41, P < 0.0001) and incremental (r = 0.35, P < 0.001) area under the postprandial triglyceride curve. Conclusions. Our findings support the concept that the content of apoC-I per VLDL particle is an important regulator of triglyceride metabolism in the fasting and postprandial state and associated with carotid athrosclerosis. |
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Authors:
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John-Bjarne Hansen; José A Fernández; Ann-Trude With Notø; Hiroshi Deguchi; Johan Björkegren; Ellisiv B Mathiesen |
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Publication Detail:
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Type: Journal Article Date: 2011-07-06 |
Journal Detail:
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Title: Journal of lipids Volume: 2011 ISSN: 2090-3049 ISO Abbreviation: J Lipids Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101553819 Medline TA: J Lipids Country: Egypt |
Other Details:
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Languages: eng Pagination: 271062 Citation Subset: - |
Affiliation:
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Hematology Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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