| Is aperistalsis with complete lower esophageal sphincter relaxation an early stage of classic achalasia? | |
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MedLine Citation:
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PMID: 17376048 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aperistalsis with complete lower esophageal sphincter (LES) relaxation, characterized by the complete relaxation of the LES and aperistalsis of the esophageal body on manometry, has been considered by some authors to be an early manifestation of classic achalasia, which is defined as incomplete relaxation of the LES and aperistalsis of the esophageal body. The aim of the present study was to compare the clinical features of patients with aperistalsis with complete LES relaxation, with those of patients with classic achalasia. METHODS: Eighteen patients with aperistalsis with complete LES relaxation and 53 patients with classic achalasia were analyzed with regard to clinical history, the maximal diameter of the esophageal body on barium esophagogram, LES resting pressure and the duration of LES relaxation on manometric recordings, and the selected treatment and its efficacy. RESULTS: The aperistalsis with complete LES relaxation group had distinctly different features compared to those of the classic achalasia group including older age, more frequent association with non-cardiac chest pain, less frequent association with dysphagia and weight loss, lower LES resting pressures, and longer duration of LES relaxation. However, the two groups were similar in terms of maximal diameter of the esophageal body, and efficacy associated with pneumatic dilation. CONCLUSIONS: Aperistalsis with complete LES relaxation on manometry is not necessarily an early manifestation of classic achalasia. However, this condition does not preclude a diagnosis of achalasia or a good response to achalasia therapy. |
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Authors:
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Jeong Hwan Kim; Poong-Lyul Rhee; Sang Soo Lee; Hyuk Lee; Yong Sung Choi; Hee Jung Son; Jae J Kim; Jong Chul Rhee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 22 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-22 Completed Date: 2007-06-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 536-41 Citation Subset: IM |
Affiliation:
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Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Balloon Dilatation Esophageal Achalasia / diagnosis*, etiology Esophageal Motility Disorders / physiopathology* Esophageal Sphincter, Lower / physiopathology* Esophagus / radiography Female Humans Male Manometry Middle Aged Muscle Relaxation / physiology* Peristalsis / physiology* Retrospective Studies |
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