| Is the aortic root dilated in obstructive sleep apnoea syndrome? | |
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MedLine Citation:
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PMID: 18809152 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obstructive sleep apnoea syndrome (OSAS) is associated with an increased risk of arterial hypertension (AH), coronary artery disease, atrial arrhythmias, heart failure, stroke and death. Whether OSAS influences aortic root size has not been fully investigated. The aim of our study was to investigate aortic root diameter and aortic stiffness in OSAS. METHODS: Using transthoracic Doppler echocardiography, we evaluated 76 patients with OSAS (mean age 52.7 +/- 9.5 years, 70 men [92%]) with no overt cardiovascular disease. The following parameters were measured offline: aortic diameter at Valsalva sinuses, aortic regurgitation (AR) grade, left ventricular (LV) mass, LV ejection fraction (LVEF, Simpson rule), systolic pulmonary artery pressure (sPAP). Aortic stiffness (carotid-femoral pulse wave velocity, PWV) was measured non-invasively using SphygmoCor technology. RESULTS: Mean duration of OSAS was four years and 84% of patients were being treated with continuous positive airway pressure. AH was documented in 39 (51%) patients. The mean aortic root diameter was 35.3 +/- 3.8 mm (26.9-44.6 mm) and the prevalence of aortic root dilatation was 3.9% (3 of 76 patients). On univariate analysis, age and sex were significant predictors of aortic root dilatation whereas arterial hypertension was not. CONCLUSIONS: The prevalence of aortic root enlargement was not increased in OSAS. Only age and sex and not arterial hypertension, were associated with aortic dilatation. |
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Authors:
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Catherine Meuleman; Franck Boccara; Xuan-Lan Nguyen; Emanuele Di Angelantonio; Stéphane Ederhy; Sandra Janower; Ghislaine Dufaitre; Nabila Haddour; Louise Boyer-Chatenet; Dominique Rakotonanahary; Bernard Fleury; Ariel Cohen |
Publication Detail:
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Type: Journal Article Date: 2008-08-28 |
Journal Detail:
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Title: Archives of cardiovascular diseases Volume: 101 ISSN: 1875-2136 ISO Abbreviation: Arch Cardiovasc Dis Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-09-23 Completed Date: 2008-12-18 Revised Date: 2011-04-25 |
Medline Journal Info:
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Nlm Unique ID: 101465655 Medline TA: Arch Cardiovasc Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 391-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Saint-Antoine University and Medical School, Université Pierre-et-Marie-Curie, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aorta / pathology*, physiopathology, ultrasonography Carotid Arteries / physiopathology, ultrasonography Cohort Studies Dilatation, Pathologic / complications, physiopathology* Echocardiography, Doppler* Elasticity Humans Male Middle Aged Polysomnography / methods Pulsatile Flow Retrospective Studies Sex Factors Sleep Apnea, Obstructive / complications, pathology, physiopathology*, ultrasonography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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