| An aortic aneurysm model for the evaluation of endovascular exclusion prostheses. | |
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MedLine Citation:
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PMID: 7674474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The purpose of this study was to develop an aortic aneurysm (AA) model with a predictable tendency for rupture for the evaluation of the efficacy of endovascular prostheses in preventing rupture and their long-term outcome after implantation. METHODS: An infrarenal AA measuring two to three times the diameter of the proximal aorta was created in 18 dogs with a full-thickness patch of jejunum. Seven dogs were allowed to survive without aneurysm exclusion. In 11 dogs the aneurysm was immediately excluded with a stented 8 mm Dacron graft mounted in a 14F delivery system introduced through the femoral artery with aortographic guidance. The pressure differential between the aorta and the excluded aneurysm was measured, and angiography, necropsy, and histologic examination were performed at 3- and 6-month survival. RESULTS: All animals survived aneurysm implantation. Without aneurysm exclusion, six dogs died of rupture within 1 to 6 days of surgery. In three dogs the exclusion failed because of graft-to-aorta size mismatch or misplacement demonstrated on angiography and by a low pressure differential between the aorta and the aneurysm (< 5 mm Hg); all three dogs died of rupture within 4 days. In eight dogs the aneurysm was successfully excluded on the basis of angiography results, with a mean aorta-to-aneurysm pressure differential of 51 mm Hg. Two dogs were killed at 1 and 6 days after surgery because of paraplegia produced by graft thrombosis because of kinking but without evidence of aneurysm rupture. Six dogs survived on a long-term basis, and angiography and necropsy performed at 3 and 6 months revealed patent grafts without migration, reduction in aneurysm size, no flow in the excluded lumbar arteries in five of six animals, and complete incorporation of Dacron graft and stents. No evidence of graft infection was found in any animal. The survival rate was significantly better (p < 0.023) in dogs with successfully excluded aneurysms (n = 6) compared with that in dogs without exclusion or with failed aneurysm exclusion (n = 7). CONCLUSION: This aneurysm model demonstrates that without effective aneurysm exclusion all animals die of rupture and that successfully placed endovascular prostheses can prevent AA rupture with long-term graft patency and stability. Endovascular aortic Dacron grafts in dogs undergo complete incorporation at 3 months from implantation. This aneurysm model is useful for the evaluation of endovascular devices designed for the treatment of AAs. |
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Authors:
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E Criado; W A Marston; J T Woosley; J Ligush; T A Chuter; C Baird; C A Suggs; M A Mauro; B A Keagy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of vascular surgery Volume: 22 ISSN: 0741-5214 ISO Abbreviation: J. Vasc. Surg. Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-10-18 Completed Date: 1995-10-18 Revised Date: 2012-10-03 |
Medline Journal Info:
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Nlm Unique ID: 8407742 Medline TA: J Vasc Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 306-14; discussion 314-5 Citation Subset: IM |
Affiliation:
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Departments of Surgery, University of North Carolina, Chapel Hill 27599-7212, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / pathology Aortic Aneurysm, Abdominal / pathology, physiopathology, surgery* Aortic Rupture / prevention & control Blood Vessel Prosthesis* Disease Models, Animal* Dogs Male |
| Comments/Corrections | |
Comment In:
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J Vasc Surg. 1996 Apr;23(4):736-7
[PMID:
8627916
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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