| The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus. | |
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MedLine Citation:
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PMID: 17970694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Influenza A virus (FLUAV) is an important human pathogen able to cause devastating pandemics. Recently, cotton rats have been proposed as an animal model to study the innate immune response against FLUAV and other human pathogens. The interferon (IFN)-induced Mx GTPases are part of the cell-autonomous innate immune response against viruses. We, therefore, tested the antiviral activity of the two cotton rat Mx proteins that were recently identified. The nuclear cotton rat Mx1 protein was found to be a strong inhibitor of FLUAV, whereas the cytoplasmic cotton rat Mx2 protein was inactive. Cotton rat Mx2, but not cotton rat Mx1, was able to inhibit the rhabdovirus vesicular stomatitis virus (VSV) and the bunyavirus Rift Valley fever virus (RVFV) known to replicate in the cytoplasm of infected cells. Thus, cotton rats possess two Mx proteins that have selective antiviral activity that depends on their intracellular localization. We conclude that the Mx status of cotton rats differs from that of conventional inbred mouse strains, which are known to have defective Mx genes. Therefore, cotton rats are a suitable animal model to study experimental infections with FLUAV and other RNA viruses. |
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Authors:
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Silke Stertz; Jan Dittmann; Jorge C G Blanco; Lioubov M Pletneva; Otto Haller; Georg Kochs |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Volume: 27 ISSN: 1079-9907 ISO Abbreviation: J. Interferon Cytokine Res. Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-31 Completed Date: 2008-04-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9507088 Medline TA: J Interferon Cytokine Res Country: United States |
Other Details:
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Languages: eng Pagination: 847-55 Citation Subset: IM |
Affiliation:
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Abteilung Virologie, Institut Für Medizinische Mikrobiologie Und Hygiene, Universität Freiburg, D-79008 Freiburg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antiviral Agents / metabolism* Cell Line Cell Nucleus / drug effects, metabolism Cercopithecus aethiops Cytoplasm / drug effects, metabolism GTP-Binding Proteins / genetics, metabolism* Humans Interferons / pharmacology* Orthobunyavirus / physiology* Orthomyxoviridae / physiology* Protein Transport / drug effects Rhabdoviridae / physiology* Sigmodontinae / genetics, metabolism*, virology* Vero Cells Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/myxovirus resistance proteins; 9008-11-1/Interferons; EC 3.6.1.-/GTP-Binding Proteins |
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