Document Detail

The antipyretic effect of flurbiprofen.
MedLine Citation:
PMID:  330173     Owner:  NLM     Status:  MEDLINE    
Flurbiprofen, like its predecessor ibuprofen, possesses antipyretic properties in the endotoxin-fevered rabbit. Comparison of flurbiprofen and ibuprofen at varying dosages, reveals that flurbiprofen is at least 15 times more potent in this species. In goats, flurbiprofen is more potent than in rabbits. Flurbiprofen inhibited the pyrogenic effect of intravenously administered leucocytic pyrogen, but it did not alter the release of leucocytic pyrogen from peritoneal exudate cells in vitro. Moreover, flurbiprofen did not inhibit endotoxin-induced release of endogenous pyrogen in vivo. Incubation of leucocytic pyrogen with flurbiprofen did not alter its pyrogenic poteny. These results suggest that the antipyretic activity of flurbiprofen is due neither to interference with endogenous pyrogen synthesis and release, nor to inactivation of circulating endogenous pyrogen.
A S Van Miert; C T Van Duin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  44     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-14     Completed Date:  1977-10-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  197-204     Citation Subset:  IM    
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MeSH Terms
Depression, Chemical
Escherichia coli
Fever / chemically induced,  physiopathology
Flurbiprofen / pharmacology*
Leukocytes / drug effects,  metabolism
Lipopolysaccharides / pharmacology
Propionates / pharmacology*
Pyrogens / blood,  pharmacology
Salmonella typhimurium
Time Factors
Reg. No./Substance:
0/Analgesics; 0/Lipopolysaccharides; 0/Propionates; 0/Pyrogens; 5104-49-4/Flurbiprofen

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