Document Detail

Is antipsychotic treatment linked to low bone mineral density and osteoporosis? A review of the evidence and the clinical implications.
MedLine Citation:
PMID:  22228316     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Osteoporosis is increasingly common worldwide and there is a growing concern that the long-term use of antipsychotic medications increases the risk of this disorder. In this review, we consider whether antipsychotics may contribute to the development of osteoporosis through reductions in bone mineral density, discuss the possible mechanisms involved and consider the clinical implications of such a relationship.
METHODS: We searched the literature for studies in this area published between 1966 and 2010 using the Medline and PubMed databases, supplemented by hand searches of retrieved reports.
RESULTS: The available data indicate that statistically significant reductions in bone mineral density are frequently seen in patients prescribed with antipsychotic medications and suggest that there is a higher incidence of clinically significant reductions compared with the normal population.
CONCLUSIONS: Clinicians should be aware for the potential negative effects of antipsychotic medications on bone mineral density, particularly in patients with additional risk factors for osteoporosis. Recommendations regarding routine monitoring of bone mineral density for patients prescribed antipsychotic medications cannot be made on the basis of existing evidence, and more research is required.
Matthieu P K Crews; Oliver D Howes
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-01-09
Journal Detail:
Title:  Human psychopharmacology     Volume:  27     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-26     Completed Date:  2012-06-29     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-23     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
South London and Maudsley NHS Foundation Trust, The Maudsley Hospital, Denmark Hill, London, SE5 8AZ, UK.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use
Bone Density / drug effects*
Drug Monitoring
Osteoporosis / epidemiology,  etiology*
Risk Factors
Schizophrenia / drug therapy
Grant Support
MC_U120097115//Medical Research Council
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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