| The antioxidant glutathione peroxidase family and spermatozoa: a complex story. | |
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MedLine Citation:
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PMID: 16427183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative damage is one threat spermatozoa have to face during epididymal maturation and storage. However, it is clear that reactive oxygen species (ROS) are also central for sperm physiology in processes such as sperm maturation and capacitation. It is therefore essential that there exists around sperm cells a fine balance between ROS production and recycling. To do so, sperm cells and epididymal epithelial cells rely on common enzymatic ROS scavengers such as superoxide dismutase (SOD), glutathione peroxidases (GPX) and catalase (CAT) as well as more specific types such as indoleamine dioxygenase (IDO). Among the catalytic triad (SOD/GPX/CAT), the glutathione peroxidase protein family occupies a peculiar position, since several GPX have been found to be present on and around epididymal transiting sperm cells. Here, we will review our present knowledge regarding GPX expression, presence and putative role(s) within the epididymis and on spermatozoa. Taking into account our recent findings regarding the epididymal expression of indoleamine dioxygenase in mouse we will also discuss how we think this superoxide anion recycling enzyme completes the complex ROS generation/recycling balance in this organ. |
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Authors:
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Joël R Drevet |
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Publication Detail:
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Type: Journal Article; Review Date: 2006-01-19 |
Journal Detail:
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Title: Molecular and cellular endocrinology Volume: 250 ISSN: 0303-7207 ISO Abbreviation: Mol. Cell. Endocrinol. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-05-08 Completed Date: 2006-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7500844 Medline TA: Mol Cell Endocrinol Country: Ireland |
Other Details:
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Languages: eng Pagination: 70-9 Citation Subset: IM |
Affiliation:
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Université Blaise Pascal, CNRS UMR 6547 GEEM, 24 Avenue des Landais, 63177 Aubière, France. joel.drevet@univ-bpclermont.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Epididymis / enzymology* Free Radical Scavengers / metabolism* Glutathione Peroxidase / metabolism* Male Mice Reactive Oxygen Species / metabolism Sperm Maturation* Spermatozoa / enzymology* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Free Radical Scavengers; 0/Reactive Oxygen Species; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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