Document Detail


The antioxidant enzymatic blood profile in Alzheimer's and vascular diseases. Their association and a possible assay to differentiate demented subjects and controls.
MedLine Citation:
PMID:  8880696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A study of several elements of the antioxidative system: Cu-Zn superoxide dismutase (SOD), catalase (CAT), glutathione system (GLU), chemiluminescence (CHE), and antioxidant capacity (AOX), was conducted in 20 demented probable Alzheimer's (DAT), and 15 vascular demented (VD) patients, 19 control (C) subjects, and 11 relatives (F) of one DAT patient. A significant association was found between the variables of the antioxidant system, measured in blood samples, and the neurological pathologies VD and DAT: Kruskal-Wallis test; p = 0.0006 (p = 0.014 when the analysis did not include SOD). This demonstrated that VD and DAT diseases are accompanied by oxidative disorders. The VD and DAT diseases are differentially distinguishable by changes in blood profiles. A graphical method for classification, the Principal Components Analysis (PCA), distinguished between demented and non-demented subjects on the basis of their laboratory variables. A numerical method, Discriminant Functions (DF), constructed to separate the clinical groups on the basis of the same variables, obtained relatively high percentages of success: 92% of demented were detected against healthy subjects; of the latter 82% have been correctly identified as non-demented. Discrimination between VD and DAT patients was achieved for 100% of VD and 86% of DAT patients. DF were similarly successful in detecting the healthy condition of DAT relatives. Possible different mechanisms involved in H2O2 elimination in DAT and VD patients are proposed, where CAT is the responsible enzyme of this reaction in DAT patients, while in VD this function would be achieved mainly through the action of GLU. It seems that SOD levels are stable, at least, within one year. Variations appear to be linked with clinical changes.
Authors:
A L Famulari; E R Marschoff; S F Llesuy; S Kohan; J A Serra; R O Dominguez; M Repetto; C Reides; E Sacerdote de Lustig
Related Documents :
19259976 - Voxel based morphometry features and follow-up of amnestic patients at high risk for al...
16960446 - The role of 123i-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of le...
3123626 - Effect of the application of a mucin-based saliva substitute on the oral microflora of ...
20385916 - What is semantic dementia?: a cohort study of diagnostic features and clinical boundaries.
11129006 - Diagnosis and management of the lateralized tympanic membrane.
7432726 - Urinary bladder distention: effect on labor and uterine activity.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  141     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-17     Completed Date:  1997-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  69-78     Citation Subset:  IM    
Affiliation:
Hospital Sirio-Libanés, FACENE, Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Alzheimer Disease / blood*,  diagnosis,  enzymology*
Antioxidants / metabolism*
Biological Markers
Catalase / blood
Chemiluminescent Measurements
Data Interpretation, Statistical
Diagnosis, Differential
Erythrocytes / enzymology
Family Health
Free Radicals
Glutathione / metabolism
Humans
Oxidative Stress / physiology
Superoxide Dismutase / blood
Vascular Diseases / blood*,  diagnosis,  enzymology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Biological Markers; 0/Free Radicals; 70-18-8/Glutathione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Amyloid beta protein in plasma from patients with sporadic Alzheimer's disease.
Next Document:  Language functions in incipient cognitive decline in multiple sclerosis.