Document Detail


The antimicrobial peptide PR-39 has a protective effect against HeLa cell apoptosis.
MedLine Citation:
PMID:  17683376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PR-39 is a cathelicidin with antimicrobial properties, which acts as a suppressor of inflammation and exerts a number of additional activities. We investigated for the first time the effect of PR-39 on human cells, by addressing the possible interference with HeLa cell metabolism. We observed that the continuous administration of PR-39 to HeLa cell cultures was not cytotoxic and did not interfere with DNA synthesis. When used in combination with a panel of drugs inducing apoptosis through different mechanisms of action, i.e. etoposide, bleomycin, tert-butylhydroperoxide and 2-deoxy-d-ribose, PR-39 attenuated the apoptotic response of HeLa cells.
Authors:
Christopher R Ross; Giovanni Ricevuti; Anna Ivana Scovassi
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Chemical biology & drug design     Volume:  70     ISSN:  1747-0277     ISO Abbreviation:  -     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262549     Medline TA:  Chem Biol Drug Des     Country:  England    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antimicrobial Cationic Peptides / pharmacology*
Apoptosis / drug effects*
Bleomycin / antagonists & inhibitors
Cell Survival / drug effects
DNA / biosynthesis
Deoxyribose / antagonists & inhibitors
Etoposide / antagonists & inhibitors
Hela Cells
Humans
tert-Butylhydroperoxide / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 11056-06-7/Bleomycin; 139637-11-9/PR 39; 33419-42-0/Etoposide; 533-67-5/Deoxyribose; 75-91-2/tert-Butylhydroperoxide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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