| The antimicrobial function of milk lipids. | |
| | |
MedLine Citation:
|
PMID: 11795045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Milk lipids serve not only as nutrients but as antimicrobial agents that constitute a defense system against microbial infections that occur at mucosal surfaces. The lipid fraction of milk develops antimicrobial activity in the gastrointestinal tract of suckling neonates as a result of lipolytic activity which converts milk triglycerides to antimicrobial fatty acids and monoglycerides. Antimicrobial milk lipids may be particularly important in protecting infants with an inadequate secretory immune response from infection. The lipid-dependent antimicrobial activity of milk is due to medium-chain saturated and long-chain unsaturated fatty acids and their respective monoglycerides released by lipases in the gastrointestinal tract. The antimicrobial activity of fatty acids and monoglycerides is additive and consequently it is their combined concentration that determines the lipid-dependent antimicrobial activity of milk. Microbial inactivation occurs rapidly by membrane destabilization. The antimicrobial activity of milk lipids can be duplicated using purified fatty acids and monoglycerides. It should be possible, therefore, to supplement banked human milk to provide lipid-dependent antimicrobial activity from the moment of ingestion (Schanler et al., 1986). This could reduce the risk of viral transmission from mother to infant through milk. Milk lipids also could be adapted for use at mucosal surfaces other than those in the gastrointestinal tract to reduce vertical transmission of pathogens during birth. |
| | |
Authors:
|
C E Isaacs |
Related Documents
:
|
6675645 - Qualitative and quantitative changes in milk fat during lactation in the tammar wallaby... 12373615 - An investigation of orotic acid levels in the breastmilk of smoking and non-smoking mot... 9577985 - The effect of intrinsic fluoride in cows' milk on in vitro enamel demineralization. 9871355 - Natural milk fatty acids affect survival and invasiveness of listeria monocytogenes. 5152025 - Effect of p-nitromethylamphetamine on biogenic amines and their amino-acid precursors i... 11347295 - The influence of dietary nucleotides and long-chain polyunsaturated fatty acids on the ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
|
Title: Advances in nutritional research Volume: 10 ISSN: 0149-9483 ISO Abbreviation: Adv Nutr Res Publication Date: 2001 |
Date Detail:
|
Created Date: 2002-01-17 Completed Date: 2002-08-01 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7802764 Medline TA: Adv Nutr Res Country: United States |
Other Details:
|
Languages: eng Pagination: 271-85 Citation Subset: IM |
Affiliation:
|
Department of Developmental Biochemistry, Institute for Basic Research, 1050 Forest Hill Road, Staten Island, NY 10314, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antiviral Agents
/
therapeutic use Female Humans Infant Infant, Newborn Infectious Disease Transmission, Vertical / prevention & control* Lipids / immunology*, pharmacology, therapeutic use Milk, Human / chemistry*, immunology |
| Grant Support | |
ID/Acronym/Agency:
|
AI39061/AI/NIAID NIH HHS; HL41179/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Antiviral Agents; 0/Lipids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Breast milk transmission of viral disease.
Next Document: Milk banking: the influence of storage procedures and subsequent processing on immunologic component...