Document Detail

The antimicrobial effect of MTAD, sodium hypochlorite, doxycycline, and citric acid on Enterococcus faecalis.
MedLine Citation:
PMID:  17185124     Owner:  NLM     Status:  MEDLINE    
This study compared the antimicrobial effect of MTAD, two of its components, doxycycline and citric acid, and sodium hypochlorite (NaOCl) in two in vitro models on Enterococcus faecalis. In the bovine tooth model, the lumens of 30 bovine dentin discs were infected with E. faecalis for 2 weeks before treating with either one of the experimental irrigants or saline. Bacteria in the shavings were collected with two sizes of burs and enumerated after overnight culturing. Zones of inhibition were recorded in the agar diffusion model for each irrigant. In the tooth model, NaOCl and doxycycline were more effective than control in killing E. faecalis at the shallow bur depth, but at the deeper bur depth only NaOCl was superior. In the agar diffusion model, NaOCl produced less inhibition than MTAD or doxycycline.
Trisha A Krause; Frederick R Liewehr; Chin-Lo Hahn
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-27
Journal Detail:
Title:  Journal of endodontics     Volume:  33     ISSN:  0099-2399     ISO Abbreviation:  J Endod     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-30     Citation Subset:  D    
Virginia Commonwealth University, Richmond, Virginia, USA.
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MeSH Terms
Anti-Infective Agents / therapeutic use*
Citric Acid / chemistry,  therapeutic use*
Doxycycline / chemistry,  therapeutic use*
Enterococcus faecalis / drug effects*
Polysorbates / chemistry,  therapeutic use*
Root Canal Irrigants / therapeutic use*
Sodium Hypochlorite / therapeutic use
Tooth Root / microbiology
Reg. No./Substance:
0/Anti-Infective Agents; 0/MTAD (intracanal irrigant); 0/Polysorbates; 0/Root Canal Irrigants; 564-25-0/Doxycycline; 7681-52-9/Sodium Hypochlorite; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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