| The antiinflammatory effect of dopamine in alcoholic hemorrhagic pancreatitis in cats. Studies on the receptors and mechanisms of action. | |
| | |
MedLine Citation:
|
PMID: 1659548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hemorrhagic pancreatitis was induced in cats by perfusing pancreatic enzymes through a pancreatic duct after the administration of intragastric ethanol. Dimethyl prostaglandin E2 was administered concurrently. In the first study, dopamine's antiinflammatory effect on the pancreas was determined in the presence of haloperidol, propranolol, or both. Next, dopamine's effects on blood flow in the normal and inflamed pancreas were compared using a hydrogen gas-clearance technique. In the final study, the effect of dopamine on fluorescein isothiocyanate-labeled dextran leakage from the pancreatic duct to portal venous blood was investigated. It was found that blockade of either dopamine or beta-adrenergic receptors reduced, and blockade of both receptors completely eliminated, the antiinflammatory effect. Dopamine had no effect on pancreatic blood flow in normal cats. In pancreatitis, although dopamine transiently reduced blood flow, after an hour flow had returned to normal. Dopamine reversed the leakage of fluorescein isothiocyanate-labeled dextran from the pancreatic duct caused by ethanol and by ethanol and prostaglandin E2. It was concluded that dopamine ameliorated pancreatitis by reducing pancreatic ductal and/or microvascular permeability rather than by altering pancreatic blood flow. The antiinflammatory effect was mediated by both dopamine and beta-adrenergic receptors. |
| | |
Authors:
|
N D Karanjia; A L Widdison; F J Lutrin; Y B Chang; H A Reber |
Related Documents
:
|
22571418 - Systemic delivery systems of angiogenic gene by novel bubble liposomes containing catio... 6584468 - Effects of local anesthetics on pulpal blood flow in dogs. 8084298 - Limits to steady-state lymph flow rates derived from plasma-to-tissue uptake measurements. 15608358 - Reefs in experimental gastroenterology--cyclic activities of the gastrointestinal tract. 2382618 - Ultrasonic clot disruption: an in vitro study. 7884288 - Flow cytometric analysis of micronuclei in the cd2+/- subpopulation of human lymphocyte... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Gastroenterology Volume: 101 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1991 Dec |
Date Detail:
|
Created Date: 1992-01-02 Completed Date: 1992-01-02 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1635-41 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, Veterans Administration Medical Center, Sepulveda, California. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Alcoholism / complications* Animals Capillary Permeability / drug effects* Cats Dopamine / pharmacology, therapeutic use* Ethanol / pharmacology Haloperidol / pharmacology Hemorrhage / drug therapy*, etiology, pathology Pancreas / blood supply, drug effects*, pathology Pancreatitis / drug therapy*, etiology, pathology Propranolol / pharmacology Prostaglandins E / pharmacology Receptors, Adrenergic, beta / drug effects, immunology Receptors, Dopamine / drug effects, immunology |
| Grant Support | |
ID/Acronym/Agency:
|
DK 37553-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Prostaglandins E; 0/Receptors, Adrenergic, beta; 0/Receptors, Dopamine; 52-86-8/Haloperidol; 525-66-6/Propranolol; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
Next Document: Spontaneous bacterial peritonitis in patients with hepatitis B-related cirrhosis and hepatocellular ...