| The antihypertensive effects of quercetin in a salt-sensitive model of hypertension. | |
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MedLine Citation:
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PMID: 18356687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salt-sensitive hypertension can be caused through abnormalities related to sodium and body fluid homeostasis; renin-angiotensin-aldosterone (RAAS) plays a key role in this regard. The molecular basis of the purported antihypertensive benefits of some plant-derived compounds such as quercetin is still lacking. To this end, we investigated RAAS in the Dahl salt-sensitive rat model with emphasis on the kidney. Eighteen rats were treated with captopril (CAP), quercetin (QUE), and dimethyl sulfoxide (controls) over a 4-week period. CAP and QUE lowered systolic blood pressure significantly in comparison to day 0 (baseline values). These findings were in keeping with their increased urinary output, increased sodium output, decreased aldosterone and decreased AT1a mRNA. QUE did not differ significantly from controls with regards to aldosterone levels. QUE was effective in lowering blood pressure in this model of hypertension, probably because of a modulation of renal function. |
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Authors:
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I Mackraj; T Govender; S Ramesar |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 51 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-21 Completed Date: 2008-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 239-45 Citation Subset: IM |
Affiliation:
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Discipline of Human Physiology, School of Basic and Applied Medical Sciences, University of KwaZulu-Natal, Durban, South Africa. mackraji@ukzn.ac.za |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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metabolism Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects* Captopril / pharmacology Dimethyl Sulfoxide / pharmacology Disease Models, Animal Hypertension / drug therapy* Kidney / drug effects, metabolism Male Quercetin / pharmacology* RNA, Messenger / drug effects, metabolism Rats Rats, Inbred Dahl Receptor, Angiotensin, Type 1 / drug effects, metabolism Sodium Chloride, Dietary / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/RNA, Messenger; 0/Receptor, Angiotensin, Type 1; 0/Sodium Chloride, Dietary; 117-39-5/Quercetin; 52-39-1/Aldosterone; 62571-86-2/Captopril; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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