Document Detail


The antifungal activity of mupirocin.
MedLine Citation:
PMID:  10350391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antibacterial agent mupirocin (pseudomonic acid A) is used as a topical agent in the treatment of superficial infections by Gram-positive bacteria, particularly Staphylococcus aureus. However, we demonstrate here that the compound also inhibits the growth of a number of pathogenic fungi in vitro, including a range of dermatophytes and Pityrosporum spp. It inhibited the incorporation of amino acids and precursors of RNA, but not that of acetate, by Trichophyton mentagrophytes. It also inhibited the isoleucyl-tRNA synthetase from Candida albicans, indicating a mechanism of action similar to that in bacteria. When administered topically, mupirocin was efficacious in a T. mentagrophytes ringworm model in guinea pigs. These results suggest that mupirocin could have clinical utility for superficial infections caused by dermatophytes.
Authors:
R O Nicholas; V Berry; P A Hunter; J A Kelly
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  43     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-10-12     Completed Date:  1999-10-12     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  579-82     Citation Subset:  IM    
Affiliation:
SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426, USA. richard_o_nicholas@sbphrd.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Animals
Antifungal Agents / pharmacology*,  therapeutic use
Candida albicans / drug effects,  enzymology
Female
Fungi / drug effects*
Guinea Pigs
Isoleucine-tRNA Ligase / antagonists & inhibitors,  metabolism
Malassezia / drug effects
Microbial Sensitivity Tests
Mupirocin / pharmacology*,  therapeutic use
Tinea / drug therapy*,  microbiology
Trichophyton / drug effects
Chemical
Reg. No./Substance:
0/Antifungal Agents; 12650-69-0/Mupirocin; EC 6.1.1.5/Isoleucine-tRNA Ligase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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