Document Detail

The antidepressant role of dietary long-chain polyunsaturated n-3 fatty acids in two phases in the developing brain.
MedLine Citation:
PMID:  18378130     Owner:  NLM     Status:  MEDLINE    
In this work we investigated the effect from fish oil (FO) supplementation, rich in n-3 fatty acids, on an antidepressant effect on adult rats in Phase A (supplementation during pregnancy and lactation) and phase B (supplementation during post-weaning until adulthood). During Phase A, female rats, used as matrix to obtain male rats, were divided in three groups: FO (daily supplemented), CF (coconut fat daily supplemented) and control (not supplemented). Our results showed that adult rats whose mothers were supplemented with FO during Phase A and rats supplemented during phase B demonstrated a significantly decreased immobility time when compared to control and CF groups. There was no difference in neither motor activity nor anxiety behavior in the three groups excluding false positive results. Our results suggest that n-3 fatty acids supplementation during Phases A and B had a beneficial effect on preventing the development of depression-like behavior in adult rats.
Anete Curte Ferraz; Agata Kiss; Renata Lins Fuentes Araújo; Hélidy Maria Rossi Salles; Katya Naliwaiko; Juliana Pamplona; Francesca Matheussi
Publication Detail:
Type:  Journal Article     Date:  2008-04-02
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  78     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Laboratório de Neurofisiologia, Departamento de Fisiologia, Universidade Federal do Paraná, Curitiba, PR, Brazil.
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MeSH Terms
Antidepressive Agents / administration & dosage,  pharmacology
Brain / drug effects,  growth & development*
Dietary Supplements*
Fatty Acids, Omega-3 / administration & dosage,  pharmacology*
Maze Learning / drug effects,  physiology
Motor Activity / drug effects,  physiology
Rats, Wistar
Reg. No./Substance:
0/Antidepressive Agents; 0/Fatty Acids, Omega-3

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