Document Detail


The anticardiolipin antibody in elderly stroke patients: its effects on stroke types, recurrence, and the coagulation-fibrinolysis system.
MedLine Citation:
PMID:  7801744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anticardiolipin antibody (aCL) is known as a risk marker for stroke, particularly in subjects younger than 50 years of age. We studied the effects of aCL on stroke types, recurrences, and the coagulation-fibrinolysis system in 257 elderly patients (63.2 +/- 11.4 years). Follow-up was performed for 3.1 years on 184 patients, for whom the rate of symptomatic and asymptomatic reinfarcts on CT was studied. aCL was positive in 30 (12%) of the patients. The incidence of atherosclerotic changes in the cerebral arteries was not significantly different between aCL-positive and aCL-negative patients. The aCL-positive patients had a greater rate of individuals not having any of the known risk factors (p < 0.05), a greater incidence of cortical infarctions (p < 0.05), more frequent symptomatic recurrences (p < 0.05). They had significantly greater changes in molecular markers for the coagulation-fibrinolysis system in the acute phase (p < 0.05), but not in the chronic phase.
Authors:
H Tohgi; H Takahashi; M Kashiwaya; K Watanabe; K Hayama
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  90     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-25     Completed Date:  1995-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  86-90     Citation Subset:  IM    
Affiliation:
Department of Neurology, Iwate Medical University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Antibodies, Anticardiolipin / analysis*
Blood Coagulation Factors / analysis*
Blood Coagulation Tests
Cerebrovascular Disorders / classification,  diagnosis*,  immunology
Female
Fibrinolysis / immunology*
Humans
Male
Middle Aged
Recurrence
Risk Factors
Chemical
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Blood Coagulation Factors
Comments/Corrections
Comment In:
Acta Neurol Scand. 1995 Jun;91(6):514-5   [PMID:  7572050 ]

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