| The antibacterial efficacy of an aceraceous plant [Shantung maple (Acer truncatum Bunge)] may be related to inhibition of bacterial beta-oxoacyl-acyl carrier protein reductase (FabG). | |
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MedLine Citation:
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PMID: 18208374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polyphenols, including flavonoids, are the major components of the extracts from aceraceous plants. They possess remarkable antibacterial and antitumour activity. Our study focused on whether the inhibition of the bacterial type II fatty acid synthesis system is the mechanism for the antibacterial effect of the related plant polyphenols. Extracts obtained from the fallen leaves of the Shantung maple (Acer truncatum Bunge) using different solvents, and the related pure compound PGG (1,2,3,4,6-penta-O-galloyl-beta-D-glucose), potently inhibited the FabG (beta-oxoacyl-ACP reductase) steps in the fatty-acid-elongation cycle with the IC(50) values between 0.9 and 7.2 microg/ml. An ethyl acetate extract appeared to inhibit FabG reductase in a mixed manner with NADPH, as did PGG with NADPH, demonstrating that they interfered with the binding of the cofactor to the enzyme. Gram-positive and Gram-negative bacteria and some fungi were used to evaluate the antibacterial abilities of different extract samples. The experiments showed that a higher polyphenol content of the extracts led to a more potent inhibitory capacity against FabG, thus enhancing the antibacterial efficacy. |
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Authors:
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Feng Zhang; Shi-Yun Luo; Yan-Bin Ye; Wen-Hua Zhao; Xu-Guang Sun; Zhi-Qun Wang; Ran Li; Ying-Hui Sun; Wei-Xi Tian; Ying-Xia Zhang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology and applied biochemistry Volume: 51 ISSN: 1470-8744 ISO Abbreviation: Biotechnol. Appl. Biochem. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-16 Completed Date: 2008-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8609465 Medline TA: Biotechnol Appl Biochem Country: England |
Other Details:
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Languages: eng Pagination: 73-8 Citation Subset: IM |
Affiliation:
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Department of Chemical Biology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acer
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chemistry* Alcohol Oxidoreductases / antagonists & inhibitors*, chemistry, isolation & purification Anti-Bacterial Agents / chemistry, isolation & purification, pharmacology* Binding Sites Dose-Response Relationship, Drug Drugs, Chinese Herbal / chemistry, isolation & purification, pharmacology* Enzyme Activation / drug effects Enzyme Inhibitors / chemistry, isolation & purification, pharmacology* Escherichia coli / drug effects, enzymology* Fungi / drug effects Gram-Negative Bacteria / drug effects Gram-Positive Bacteria / drug effects Inhibitory Concentration 50 Kinetics Microbial Sensitivity Tests Plant Leaves / chemistry Species Specificity Structure-Activity Relationship Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Drugs, Chinese Herbal; 0/Enzyme Inhibitors; EC 1.1.-/Alcohol Oxidoreductases; EC 1.1.1.36/acetoacetyl-CoA reductase |
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