| The antiarrhythmic and antifibrillatory actions of bretylium and its o-iodobenzyl trimethylammonium analog, UM-360. | |
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MedLine Citation:
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PMID: 1123718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiarrhythmic, adrenergic-stimulating and blocking properties of bretylium and a structural analog UM-360, o-iodobenzyl trimethylammonium chloride, were studied in the anesthetized dog. Bretylium produced an initial sympathomimetic effect with a subsequent blockade of cardiac responses to sympathetic nerve stimulation. Bretylium was observed to produce an antifibrillatory effect when the vulnerability to fibrillation was measured as the current required to evoke ventricular fibrillation (ventricular fibrillation threshold) or the spontaneous development of ventricular fibrillation in response to a one-stage occlusion of the left anterior descending coronary artery for 20 minutes followed by release. In animals intoxicated with ouabain, however, bretylium was not effective in reversing the ventricular tachycardia. UM-360, in contrast to bretylium, did not produce adrenergic stimulation or blockade of sympathetic neuronal activity. UM-360, however, produced a marked antifibrillatory effect by increasing the electrical threshold to ventricular fibrillation and reducing the incidence of ventricular fibrillation in response to coronary artery occlusion. The results of this study suggest that the quaternary ammonium structure, as possessed by bretylium and UM-360, may be of significance with respect to the antiarrhythmic and antifibrillatory effects of these agents. |
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Authors:
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F J Kniffen; T E Lomas; R E Counsell; B R Lucchesi |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 192 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1975 Jan |
Date Detail:
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Created Date: 1975-07-01 Completed Date: 1975-07-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 120-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arrhythmias, Cardiac / chemically induced, physiopathology* Blood Pressure / drug effects Bretylium Compounds / pharmacology* Calcium Chloride / pharmacology Coronary Vessels / physiology Dogs Electric Stimulation Electrocardiography Female Heart / drug effects Heart Rate / drug effects* Heart Ventricles / drug effects Iodobenzenes / pharmacology* Male Ouabain Stellate Ganglion / physiology Tachycardia / chemically induced Time Factors Ventricular Fibrillation / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Bretylium Compounds; 0/Iodobenzenes; 10043-52-4/Calcium Chloride; 630-60-4/Ouabain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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