| The antiadrenergic effects of hypermagnesemia: an experimental study. | |
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MedLine Citation:
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PMID: 1823214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The circulatory effects of norepinephrine (4 micrograms/kg), isoproterenol (10 micrograms/kg) and phenylephrine (20 micrograms/kg) were determined in anesthetized dogs with normal plasma magnesium and with induced hypermagnesemia. Norepinephrine caused a 24% increase in heart rate and a 103% increase in the systemic vascular resistance index in normomagnesemic dogs, while with hypermagnesemia the variations were of 13% and 1%, respectively. Isoproterenol increased heart rate by 48% and 18% in dogs with normo- and hypermagnesemia, respectively. Phenylephrine increased the systemic vascular resistance index (74%) only in the normomagnesemic state. The effects of all the drugs were significantly different (P less than 0.01), without and with the simultaneous administration of magnesium sulfate (plasma magnesium, 1.3 +/- 0.2 mEq/l and 6.8 +/- 1.1 mEq/l, respectively). We conclude that acute induced hypermagnesemia antagonizes the circulatory effects of adrenergic stimulation, a fact that may explain its antiarrhythmic and hemodynamic effects during acute myocardial ischemia. |
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Authors:
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L F Barros; F Pileggi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 24 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-09-22 Completed Date: 1992-09-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 29-33 Citation Subset: IM |
Affiliation:
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Divisão de Experimentação, Faculdade de Medicina de São Paulo, Universidade de São Paulo, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Coronary Disease / physiopathology Dogs Heart Rate / drug effects Hemodynamics / drug effects* Isoproterenol / antagonists & inhibitors* Magnesium / blood*, pharmacology Norepinephrine / antagonists & inhibitors* Phenylephrine / antagonists & inhibitors* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 59-42-7/Phenylephrine; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7683-59-2/Isoproterenol |
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