Document Detail

The antiadrenergic effects of hypermagnesemia: an experimental study.
MedLine Citation:
PMID:  1823214     Owner:  NLM     Status:  MEDLINE    
The circulatory effects of norepinephrine (4 micrograms/kg), isoproterenol (10 micrograms/kg) and phenylephrine (20 micrograms/kg) were determined in anesthetized dogs with normal plasma magnesium and with induced hypermagnesemia. Norepinephrine caused a 24% increase in heart rate and a 103% increase in the systemic vascular resistance index in normomagnesemic dogs, while with hypermagnesemia the variations were of 13% and 1%, respectively. Isoproterenol increased heart rate by 48% and 18% in dogs with normo- and hypermagnesemia, respectively. Phenylephrine increased the systemic vascular resistance index (74%) only in the normomagnesemic state. The effects of all the drugs were significantly different (P less than 0.01), without and with the simultaneous administration of magnesium sulfate (plasma magnesium, 1.3 +/- 0.2 mEq/l and 6.8 +/- 1.1 mEq/l, respectively). We conclude that acute induced hypermagnesemia antagonizes the circulatory effects of adrenergic stimulation, a fact that may explain its antiarrhythmic and hemodynamic effects during acute myocardial ischemia.
L F Barros; F Pileggi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  24     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1991  
Date Detail:
Created Date:  1992-09-22     Completed Date:  1992-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM    
Divisão de Experimentação, Faculdade de Medicina de São Paulo, Universidade de São Paulo, Brasil.
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MeSH Terms
Calcium / metabolism
Coronary Disease / physiopathology
Heart Rate / drug effects
Hemodynamics / drug effects*
Isoproterenol / antagonists & inhibitors*
Magnesium / blood*,  pharmacology
Norepinephrine / antagonists & inhibitors*
Phenylephrine / antagonists & inhibitors*
Vascular Resistance / drug effects
Reg. No./Substance:
51-41-2/Norepinephrine; 59-42-7/Phenylephrine; 7439-95-4/Magnesium; 7440-70-2/Calcium; 7683-59-2/Isoproterenol

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