Document Detail


The anti-tumor agent, p-DDAP potently suppresses proliferation through apoptosis in human neuroblastoma NB-39-nu cells.
MedLine Citation:
PMID:  20580487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinoic acid (RA) is a chemotherapeutic agent used to induce neuronal cellular differentiation of neuroblastoma. However, because treatment with RA is associated with the side-effect of nyctalopia, efforts have been underway to identify new compounds that could potentially overcome these drawbacks. As part of these studies we have examined anti-cancer effects on the neuroblastoma NB-39-nu cells of p-dodecylaminophenol (p-DDAP), a novel derivative of N-(4-hydroxyphenyl) retinamide (4-HPR). p-DDAP suppresses proliferation, and induces G(0)/G(1) arrest and apoptosis to a greater extent than RA and 4-HPR. Neuronal differentiation was not detected in p-DDAP-treated cells. Since p-DDAP is not toxic and does not reduce blood retinol levels, p-DDAP might be a useful anti-neuroblastoma drug having reduced side-effects.
Authors:
Noriko Takahashi; Rumi Egawa; Masahiko Imai; Katsuhiko Takahashi; Toshihiro Ohba; Masue Imaizumi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-26
Journal Detail:
Title:  Cancer letters     Volume:  297     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  252-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University, Shinagawa, Tokyo 142-8501, Japan. t-noriko@hoshi.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aminophenols / pharmacology*
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Cell Cycle / drug effects
Cell Differentiation / drug effects
Cell Growth Processes / drug effects
Cell Line, Tumor
Down-Regulation
Humans
Neuroblastoma / drug therapy*,  pathology
Chemical
Reg. No./Substance:
0/Aminophenols; 0/Antineoplastic Agents

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