Document Detail


The anti-neoplastic effects of coumarin: an emerging concept.
MedLine Citation:
PMID:  23340967     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer surgery and radiation therapy. In one recent study, an almost 12.5 % decline in the volume of upper extremity lymphedema was noticed. As a result, quality of life is significantly improved. Similar attenuation of tumor growth has been seen in pulmonary malignancies. It mediates these anti-neoplastic effects by attenuating Bcl-2 expression within the tumor cells. On the other hand, Bax expression within the tumor cells is markedly accentuated. These changes have recently been confirmed in A549 cells.
Authors:
Shailendra Kapoor
Related Documents :
3986767 - Application of a human tumor colony-forming assay to new drug screening.
9140117 - Antitumor activity of tzt-1027, a novel dolastatin 10 derivative.
1756537 - A potent and specific immunotoxin for tumor cells expressing disialoganglioside gd2.
21165557 - Antitumor effect of endostatin overexpressed in c6 glioma cells is associated with the ...
17616437 - Are peroxiredoxins tumor suppressors?
22585997 - Suppression of tumor invasion and metastasis by concurrent inhibition of c-met and vegf...
Publication Detail:
Type:  Journal Article     Date:  2013-01-23
Journal Detail:
Title:  Cytotechnology     Volume:  65     ISSN:  0920-9069     ISO Abbreviation:  Cytotechnology     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-25     Completed Date:  2013-10-25     Revised Date:  2014-10-01    
Medline Journal Info:
Nlm Unique ID:  8807027     Medline TA:  Cytotechnology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  787-8     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Kinetic studies of recombinant rabies virus glycoprotein (RVGP) cDNA transcription and mRNA translat...
Next Document:  [Dysfunctional emotion regulation as a basic factor of anxiety and depressive disorders in adolesce...