Document Detail


The anti-neoplastic effects of coumarin: an emerging concept.
MedLine Citation:
PMID:  23340967     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer surgery and radiation therapy. In one recent study, an almost 12.5 % decline in the volume of upper extremity lymphedema was noticed. As a result, quality of life is significantly improved. Similar attenuation of tumor growth has been seen in pulmonary malignancies. It mediates these anti-neoplastic effects by attenuating Bcl-2 expression within the tumor cells. On the other hand, Bax expression within the tumor cells is markedly accentuated. These changes have recently been confirmed in A549 cells.
Authors:
Shailendra Kapoor
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Publication Detail:
Type:  Journal Article     Date:  2013-01-23
Journal Detail:
Title:  Cytotechnology     Volume:  65     ISSN:  0920-9069     ISO Abbreviation:  Cytotechnology     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-25     Completed Date:  2013-10-25     Revised Date:  2014-10-01    
Medline Journal Info:
Nlm Unique ID:  8807027     Medline TA:  Cytotechnology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  787-8     Citation Subset:  -    
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