Document Detail

The anti-gastropathic and anti-rheumatic effect of niga-ichigoside F1 and 23-hydroxytormentic acid isolated from the unripe fruits of Rubus coreanus in a rat model.
MedLine Citation:
PMID:  16651728     Owner:  NLM     Status:  MEDLINE    
This study was undertaken to produce the clinical merits of two natural antinociceptive anti-inflammatory triterpenoids which synthetic anti-inflammatory drugs do not have. The triterpenoid glycoside niga-ichigoside F1 (NIF1) and its aglycone 23-hydroxytormentic acid (23-HTA), which were isolated from the unripe fruits of Rubus coreanus (Rosaceae), reduced rheumatoid arthritis (RA) factor and C-reactive protein (CRP) factor in Freund's complete adjuvant reagent-induced rats, suggesting that these two triterpenoids had an anti-rheumatic effect. It was also shown that treatment with NIF1 or 23-HTA reduced gastric lesion extent, acidity and total gastric acid output induced by EtOH plus sodium salicylate in a gastric secretion test. Moreover, 23-HTA had a greater effect than the glycoside, NIF1. To clarify the anti-gastropathic mechanism of these two compounds, their free radical scavenging activities in the gastric mucosa were examined in a rat EtOH-sodium salicylate-induced gastropathy model. The two compounds significantly increased superoxide dismutase and glutathione peroxidase activities, indicating that the healing effects of NIF1 and 23-HTA against gastropathy are associated with free radical scavenging enzyme activities. These results support the notion that the long-term administration of NIF1 or 23-HTA should overcome the adverse effects of synthetic anti-inflammatory drugs.
Jung-Hwan Nam; Hyun-Ju Jung; Jongwon Choi; Kyung-Tae Lee; Hee-Juhn Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  29     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-02     Completed Date:  2006-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  967-70     Citation Subset:  IM    
College of Pharmacy, Kyung-Hee University, Dondaemun-ku, Korea.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal
Anti-Ulcer Agents*
Antirheumatic Agents*
Arthritis, Experimental / chemically induced,  prevention & control*
C-Reactive Protein / metabolism
Free Radical Scavengers / metabolism
Freund's Adjuvant
Fruit / chemistry
Gastric Juice / metabolism
Gastric Mucosa / drug effects,  enzymology,  metabolism
Glutathione Peroxidase / metabolism
Indicators and Reagents
Rats, Sprague-Dawley
Rosaceae / chemistry*
Saponins / chemistry,  pharmacology*
Sodium Salicylate
Stomach Ulcer / chemically induced,  prevention & control*
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Triterpenes / chemistry,  pharmacology*
Reg. No./Substance:
0/23-hydroxytormentic acid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anti-Ulcer Agents; 0/Antirheumatic Agents; 0/Free Radical Scavengers; 0/Indicators and Reagents; 0/Saponins; 0/Thiobarbituric Acid Reactive Substances; 0/Triterpenes; 54-21-7/Sodium Salicylate; 9007-41-4/C-Reactive Protein; 9007-81-2/Freund's Adjuvant; 95262-48-9/niga-ichigoside F1; EC Peroxidase; EC Dismutase

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