Document Detail

The anti-arthritic and anti-oxidative effect of NBD (6-nitro-1,3-benzodioxane) in adjuvant-induced arthritis (AIA) in rats.
MedLine Citation:
PMID:  22538965     Owner:  NLM     Status:  Publisher    
OBJECTIVES: The present study evaluated the anti-arthritic and anti-oxidative effects of 6-nitro-1,3-benzodioxane in the adjuvant-induced arthritis model in rats. METHODS: Arthritis was induced in female rats by intradermal injection of MT37Ra. Arthritis was evaluated by arthritic score, body weight loss, paw volume measurement, and histological changes. The plantar test was used to evaluate the effect of NBD on hyperalgesia. RESULTS: The hyperalgesia (p < 0.0001) and hind paw inflammation (p < 0.034) was significantly decreased with parallel increase in the body weight of the NBD-treated (25 mg/kg) group compared to arthritic control rats. The antioxidant activity analysis demonstrated that the treatment of NBD significantly suppressed the levels of nitric oxide (p < 0.001) and peroxide (p < 0.002) with a significant increase in the glutathione (p < 0.021) compared to the arthritic control group. Since the IL-1β and TNF-α are key pro-inflammatory cytokines in arthritis, we therefore measured their levels in the serum samples. In comparison to the arthritic control group, the NBD treatment significantly reduced the levels of IL-1β (p < 0.003) and TNF-α (p < 0.026). CONCLUSION: Our results suggests that NBD is an anti-arthritic agent that not only reduces the severity of the disease process but also affects contributing factors of arthritic inflammation including free radicals and inflammatory cytokines production.
Syed Uzair Ali Shah; Nadeem Ashraf; Zahid H Soomro; Muhammad Raza Shah; Nurul Kabir; Shabana Usman Simjee
Related Documents :
7622855 - Chronic hyperinsulinaemia and hypertension: the role of the sympathetic nervous system.
11226405 - Influence of phenobarbital on changes in na(+) handling, hemodynamics and liver functio...
7537235 - Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circula...
43065 - Neonatal 6-hydroxydopamine treatment increases the vulnerability of the blood-brain bar...
2803565 - Correlations between paradoxical sleep and shuttle-box conditioning in rats.
14578555 - Structural changes in the glycosaminoglycan chain of rat skin decorin with growth.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  -     ISSN:  1420-908X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Double agents in the war on cancer: leukocytes govern ovarian cancer progression.
Next Document:  Differentiated Epidermal Cells Regain the Ability to Regenerate a Skin Equivalent by Increasing the ...