| The anti-arrhythmic effect of D-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism. | |
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MedLine Citation:
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PMID: 8349385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied antiarrhythmic action of D-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. D-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin. |
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Authors:
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L N Maslov; Y B Lishmanov |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 40 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-09-10 Completed Date: 1993-09-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 89-94 Citation Subset: IM |
Affiliation:
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Tomsk Research Centre of the Russian Academy of Medical Sciences, Russian Federation. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / therapeutic use* Arrhythmias, Cardiac / etiology, prevention & control* Chi-Square Distribution Enkephalin, Leucine-2-Alanine / analogs & derivatives*, therapeutic use Male Myocardial Ischemia / complications* Rats |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 63631-40-3/Enkephalin, Leucine-2-Alanine; 81733-79-1/enkephalin-Leu, Ala(2)-Arg(6)- |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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