Document Detail

The anti-arrhythmic effect of D-Ala 2, Leu 5, Arg 6-enkephalin and its possible mechanism.
MedLine Citation:
PMID:  8349385     Owner:  NLM     Status:  MEDLINE    
We studied antiarrhythmic action of D-Ala 2, Leu 5, Arg 6-enkephalin (dalargin) in experiments on male rats. Dalargin is reported to prevent heart rhythm disturbance and heart electrical stability decrease in experimental coronary occlusion, postinfarction, cardiosclerosis and emotional stress. Dalargin prevents acute myocardial ischaemia-induced increase of cAMP content in blood serum and cardiac muscle, as an indirect feature of its antiadrenergic activity. D-Ala 2, Leu 5, Arg 6-enkephalin leads to a decrease of cAMP content in myocardium and blood plasma, which presumably indicates a decrease of sympathetic tone. The data strongly suggest that cGMP content increase and somatostatin level decrease in cardiac muscle play a significant role in antiarrhythmic action of dalargin.
L N Maslov; Y B Lishmanov
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  40     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-09-10     Completed Date:  1993-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Tomsk Research Centre of the Russian Academy of Medical Sciences, Russian Federation.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Arrhythmias, Cardiac / etiology,  prevention & control*
Chi-Square Distribution
Enkephalin, Leucine-2-Alanine / analogs & derivatives*,  therapeutic use
Myocardial Ischemia / complications*
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 63631-40-3/Enkephalin, Leucine-2-Alanine; 81733-79-1/enkephalin-Leu, Ala(2)-Arg(6)-

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