Document Detail

The anti-ageing potential of a new jasmonic acid derivative (LR2412): in vitro evaluation using reconstructed epidermis episkin™.
MedLine Citation:
PMID:  22509841     Owner:  NLM     Status:  In-Data-Review    
Jasmonic acid is involved in plant wound repair and tissue regeneration, but no study has been reported in human skin. The effect of a jasmonic acid derivative, tetra-hydro-jasmonic acid (LR2412, 1 and 10 μm) was investigated on an in vitro reconstructed skin model, Episkin™. Using real time RTQPCR studies, results showed an increase in hyaluronan synthase 2 (HAS2) and hyaluronase synthase 3 (HAS3) expression. Furthermore, an increase in hyaluronic acid (HA) deposits in basal and suprabasal layers of the epidermis was observed. The percentage of positive Ki67 keratinocytes in the basal layer as well as the epidermis thickness were seen to increase. Immunohistochemistry studies showed that the synthesis of late differentiation proteins filaggrin and transglutaminase 1 was not modified. The human epidermis is known to thin with age while HA content has been reported to decrease. These results illustrate the potential of LR2412 in counteracting signs of skin ageing.
Jean F Michelet; Christian Olive; Elodie Rieux; Dominique Fagot; Lucie Simonetti; Jean B Galey; Maria Dalko-Csiba; Bruno A Bernard; Rui Pereira
Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Experimental dermatology     Volume:  21     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  398-400     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Department of Advanced Research, L'Oréal Research & Innovation, Aulnay sous Bois, France Department of Advanced Research, L'Oréal Research & Innovation, Clichy, France.
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