Document Detail


Is antenatal steroid treatment effective in preterm IUGR fetuses?
MedLine Citation:
PMID:  19670049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are no randomized studies on the effect of antenatal corticosteroids in preterm intrauterine growth restricted (IUGR) fetuses. Fetal lung maturation has been postulated to be enhanced in these fetuses, which may result in little benefit of steroid treatment. Furthermore, corticosteroid treatment may be detrimental, as has been shown in IUGR animal models. The objective of this study was to review the available literature on antenatal steroid treatment of the IUGR fetus. All available reports on antenatal steroid treatment of IUGR and small for gestational age (SGA) fetuses published prior to October 2007 were included in this review. IUGR fetuses are a subgroup of SGA fetuses that are small due to placental insufficiency, which is reflected in abnormal Doppler examination of the umbilical artery. The main outcome measures were respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), and neonatal mortality. No difference in neonatal mortality was seen in any of the reviewed studies and RDS, IVH, and NEC incidence did not differ between treated and untreated IUGR fetuses. In SGA fetuses, results on RDS incidence and intracranial outcome were inconclusive. Antenatal steroid treatment does not seem to have an effect on neonatal mortality or morbidity in IUGR fetuses. In SGA fetuses, it remains unclear if antenatal steroid treatment is beneficial due to heterogeneous populations and treatment regimes. A randomized controlled trial should be performed to confirm prior results and answer further questions regarding antenatal steroid treatment of these fetuses.
Authors:
Helen L Torrance; Jan B Derks; Sicco A Scherjon; Lia D Wijnberger; Gerard H A Visser
Related Documents :
12749039 - Chaotic and periodic analysis of fetal magnetocardiogram recordings in growth restriction.
9110369 - Early sonographic diagnosis of fetal small left heart ventricle with a normal proximal ...
20940089 - Maternal salivary cortisol differs by fetal sex during the second half of pregnancy.
16906359 - The development of stomach during the fetal period.
1489179 - Amelioration of zidovudine-induced fetal toxicity in pregnant mice.
9203209 - First-trimester sonography of physiological midgut herniation and early diagnosis of om...
571919 - Biochemical assessment of the nutritional state of gravida of different socio-economic ...
12948099 - Twin pregnancy obtained with frozen-thawed embryos after in vitro maturation in a patie...
19019559 - Association between maternal and amniotic fluid cortisol is moderated by maternal anxiety.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1068-73     Citation Subset:  IM    
Affiliation:
Perinatal Center, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, the Netherlands. H.Torrance@umcutrecht.nl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use*
Animals
Enterocolitis, Necrotizing / prevention & control
Fetal Growth Retardation / prevention & control*
Humans
Infant Mortality
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / prevention & control*
Infant, Small for Gestational Age*
Leukomalacia, Periventricular / prevention & control
Respiratory Distress Syndrome, Newborn / prevention & control
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A subset of patients destined to develop spontaneous preterm labor has an abnormal angiogenic/anti-a...
Next Document:  Age Effects on Visual-Perceptual Processing and Confrontation Naming.