| The antagonizing effect of aspartic acid on the brain levels of monoamines and free amino acids during the development of tolerance to the physical dependence on morphine. | |
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MedLine Citation:
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PMID: 412214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since it has been shown in previous study that aspartic acid prevents the development of physical dependence on and tolerance to morphine and antagonizes the abstinence syndrom signs, the biochemical bases of that prevention were investigated in the present study. The brain contents of serotonin, DA, NA, and free amino acids of the rats given aspartic acid and morphine separately and in combination were determined. It has been observed that most of the morphine-induced changes in the brain were normalized in the group given aspartic acid and morphine together. The relative ineffectiveness of aspartic acid in normalizing some amino acid levels decreased by morphine was discussed and some logical explanations were found. |
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Authors:
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H Koyuncuoğlu; E Genc; M Güngör; L Eroğlu; H Sağduyu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychopharmacology Volume: 54 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1977 Oct |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 187-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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antagonists & inhibitors* Amino Acids / antagonists & inhibitors* Animals Aspartic Acid / pharmacology* Brain / metabolism* Cats Drug Tolerance Humans Morphine / pharmacology Morphine Dependence / metabolism* Rats Serotonin Antagonists |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Amino Acids; 0/Serotonin Antagonists; 56-84-8/Aspartic Acid; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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