Document Detail

The anorectic effect of neuropeptide AF is associated with satiety-related hypothalamic nuclei.
MedLine Citation:
PMID:  19490369     Owner:  NLM     Status:  MEDLINE    
Neuropeptide AF (NPAF), a member of the RFamide family, is encoded by the same gene as neuropeptide FF (NPFF), which causes short-term anorexia. However, reports on the role of NPAF on appetite-related process are lacking. Thus, i.c.v. injections of 4.0, 8.0 and 16.0 nmol NPAF were administered to chicks to observe its effect on food and water intake. Chicks treated with 8.0 and 16.0 nmol i.c.v. NPAF decreased both their food and water intake. Additionally, all doses of NPAF injected caused a similar reduction in whole blood glucose concentration 180 min after injection. In a second experiment, chicks that received i.c.v. NPAF had an increased number of c-Fos immunoreactive cells in the dorsomedial, paraventricular (magnocellular and parvicellular parts) and ventromedial nuclei. The arcuate nucleus and lateral hypothalamic area were not affected. In a third experiment, NPAF-treated chicks exhibited fewer feeding pecks and spent less time perching, whereas they spent an increased time in deep rest. Other behaviours, including exploratory pecking, escape attempts, defecations, distance moved, and time spent standing, sitting and preening, were not affected by NPAF injection. We conclude that NPAF causes anorectic effects that are associated with the hypothalamus.
M A Cline; B A Newmyer; M L Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  21     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-18     Completed Date:  2009-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  595-601     Citation Subset:  IM    
Department of Biology, Radford University, Radford, VA 24142, USA.
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MeSH Terms
Appetite Depressants / pharmacology*
Behavior, Animal / drug effects
Blood Glucose / drug effects
Dose-Response Relationship, Drug
Drinking / drug effects*
Eating / drug effects*
Feeding Behavior / drug effects
Hypothalamus / drug effects*,  metabolism
Injections, Intraventricular
Motor Activity / drug effects
Oligopeptides / pharmacology*
Proto-Oncogene Proteins c-fos / metabolism
Time Factors
Reg. No./Substance:
0/Appetite Depressants; 0/Blood Glucose; 0/Oligopeptides; 0/Proto-Oncogene Proteins c-fos; 99588-52-0/A18Famide

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