Document Detail


An animal origin perspective of common constituents of serum-free medium formulations.
MedLine Citation:
PMID:  10404889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum-free formulations may be << re-engineered >> to eliminate traditional protein constituents and replace their biological function with non-protein substitutes. Non-protein additives may also be obtained from animal sources. Nutrient formulations totally free of exogenous protein and containing no materials of animal origin may be designed for high density cell culture and biological production. Cell-culture medium production requires (i) strict vendor qualification and raw material specifications; (ii) scrupulous maintenance of media kitchen facility and equipment; (iii) monitoring of process water; (iv) air-handling systems and technical personnel; (v) clearly-defined manufacturing protocols to ensure correct formulation and dispensing and (vi) validated sanitization processes to guard against cross-contamination within a multi-use facility.
Authors:
D W Jayme
Related Documents :
18975169 - Growth and differentation of rat mammary epithelial cells cultured in serum-free medium.
23299699 - Viable biobanking of primary head and neck squamous cell carcinoma.
17451519 - In vitro development of cryptosporidium parvum in serum-free media.
1888499 - Quality control testing of surfaces for mammalian cell culture using cells propagated i...
20732139 - Allylamine toxicity in embryonic myocardial myocyte reaggregate cultures: the role of e...
1565839 - Macrophage heterogeneity and differentiation: defined serum-free culture conditions ind...
7580019 - Developmental potential of frozen-thawed human blastocysts.
21205999 - Fabrication of a nanofibrous scaffold with improved bioactivity for culture of human de...
3265659 - Synthesis of type ii collagen is decreased in cartilage cultured with interleukin 1 whi...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Developments in biological standardization     Volume:  99     ISSN:  0301-5149     ISO Abbreviation:  Dev. Biol. Stand.     Publication Date:  1999  
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0427140     Medline TA:  Dev Biol Stand     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
Affiliation:
Industrial Cell Culture Applications, Life Technologies, Inc., Grand Island, NY 14072, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Biological Products / chemistry,  standards
Cell Culture Techniques / standards*
Culture Media, Serum-Free / chemistry*,  standards*
Drug Industry / standards*
Chemical
Reg. No./Substance:
0/Biological Products; 0/Culture Media, Serum-Free

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Safety issues of animal products used in serum-free media.
Next Document:  The law, the AMA, and partial-birth abortion. American Medical Association.