Document Detail

An animal origin perspective of common constituents of serum-free medium formulations.
MedLine Citation:
PMID:  10404889     Owner:  NLM     Status:  MEDLINE    
Serum-free formulations may be << re-engineered >> to eliminate traditional protein constituents and replace their biological function with non-protein substitutes. Non-protein additives may also be obtained from animal sources. Nutrient formulations totally free of exogenous protein and containing no materials of animal origin may be designed for high density cell culture and biological production. Cell-culture medium production requires (i) strict vendor qualification and raw material specifications; (ii) scrupulous maintenance of media kitchen facility and equipment; (iii) monitoring of process water; (iv) air-handling systems and technical personnel; (v) clearly-defined manufacturing protocols to ensure correct formulation and dispensing and (vi) validated sanitization processes to guard against cross-contamination within a multi-use facility.
D W Jayme
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Developments in biological standardization     Volume:  99     ISSN:  0301-5149     ISO Abbreviation:  Dev. Biol. Stand.     Publication Date:  1999  
Date Detail:
Created Date:  1999-08-31     Completed Date:  1999-08-31     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0427140     Medline TA:  Dev Biol Stand     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  181-7     Citation Subset:  IM    
Industrial Cell Culture Applications, Life Technologies, Inc., Grand Island, NY 14072, USA.
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MeSH Terms
Biological Products / chemistry,  standards
Cell Culture Techniques / standards*
Culture Media, Serum-Free / chemistry*,  standards*
Drug Industry / standards*
Reg. No./Substance:
0/Biological Products; 0/Culture Media, Serum-Free

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