Document Detail

An animal model to study iron availability from human diets.
MedLine Citation:
PMID:  405035     Owner:  NLM     Status:  MEDLINE    
1. The retention of ferric- and ferrous-iron was determined in guinea-pigs and monkeys using 55Fe and 59Fe. 2. The bioavailability of Fe from two typical Indian diets based on rice and wheat was determined in humans and monkeys using a 59Fe tracer and whole-body counting. 3. The retention ratio, ferric-Fe; ferrous-Fe was 0-90 in guinea-pigs and 0-33 in monkeys, indicating that monkeys absorb ferrous-Fe preferentially. 4. In monkeys retention of Fe from the test diets, as from ferrous ascorbate was lower than that in humans. 5. When food-Fe retention was expressed in relation to inorganic-Fe retention the value for retention ratio, food Fe: inorganic Fe in monkeys was similar to that in human subjects. 6. The results indicate that the monkey can be used as a model to study Fe absorption from human diets.
B S Rao; J S Prasad; C V Sarathy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  37     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-07-29     Completed Date:  1977-07-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
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MeSH Terms
Anemia, Hypochromic / etiology*
Biological Availability
Disease Models, Animal*
Guinea Pigs
Iron / metabolism*
Iron Radioisotopes
Macaca mulatta
Whole-Body Counting
Reg. No./Substance:
0/Iron Radioisotopes; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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