Document Detail


An animal model of the relationship between systemic hypertension and repetitive episodic hypoxia as seen in sleep apnoea.
MedLine Citation:
PMID:  10607178     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Multiple factors may be responsible for acute and chronic blood pressure changes during obstructive sleep apnoea. A popular hypothesis is that recurrent episodic hypoxia stimulates chemoreceptors which, in turn, cause sympathetically mediated vasoconstriction and perhaps long-term vascular remodelling. Disruption of sleep architecture secondary to frequent arousals may also cause chronic stress which may contribute to diurnal hypertension. A less likely factor elevating blood pressure is the effect of abrupt intra-thoracic pressure changes on venous return and cardiac output. The rat responds to chronic, recurrent episodic hypocapnic hypoxia (12-s bursts of nitrogen followed by air into Plexiglas chambers, every 30 s, 7 h d-1, 2-4% nadir ambient oxygen) with sustained increase in diurnal blood pressure 11-14 mmHg). Subsequent studies reveal that carotid sinus nerve section (chemodenervation) and chemically induced peripheral sympathetic denervation with the neurotoxin 6-OH dopamine both eliminate this blood pressure-elevating effect of chronic episodic hypoxaemia. Using this model, Sprague-Dawley rats have been challenged with both eucapnic hypoxia and asphyxia and failed to show an additional blood pressure elevation above that caused by hypoxia (hypocapnic) alone. It appears that hypocapnic hypoxia creates a maximal stimulus to the sympathetic nervous system to which the addition of hypercarbia does not increase the blood pressure response. An alternative explanation is that the rat has protective mechanisms that limit the diurnal blood pressure response from further increase.
Authors:
Fletcher
Related Documents :
11832408 - Temporal increase in the reactivity of pulmonary vasculature to substance p in chronica...
1472668 - The utility of a double-lumen tube for one-lung ventilation in a variety of noncardiac ...
2554868 - Reduced systolic blood pressure elevations during maximum exercise at simulated altitudes.
8595958 - Systemic hypoxia dehydrates the space surrounding photoreceptors in the cat retina.
12409958 - Association of the d8s282 marker near the lipoprotein lipase gene locus with systolic b...
8268568 - Effects of a total artificial heart right stroke volume limiter on left-right hemodynam...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of sleep research     Volume:  4     ISSN:  1365-2869     ISO Abbreviation:  J Sleep Res     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1999-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214441     Medline TA:  J Sleep Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  71-77     Citation Subset:  -    
Affiliation:
Department of Medicine, Division of Respiratory and Environmental Medicine, Louisville Veterans Affairs Medical Center, and The University of Louisville School of Medicine, Louisville, KY, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Respiratory sinus arrhythmia during obstructive sleep apnoeas in humans.
Next Document:  Non-invasive measurement of haemodynamics during sleep apnoea.