| An animal model of placental insufficiency-induced intrauterine growth restriction. | |
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MedLine Citation:
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PMID: 18482626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrauterine growth restriction (IUGR), often associated with functional placental insufficiency, results in increased perinatal mortality and morbidity. For obvious reasons, many questions regarding the progression of IUGR pregnancies cannot be addressed experimentally in humans, predicating the use of animal models. Although no animal model fully recapitulates human pregnancy, the pregnant sheep has been used extensively to investigate maternal-fetal interactions. In sheep, surgical placement of catheters in both the maternal and fetal vasculature allows repeated sampling from nonanesthetized pregnancies. Considerable insight has been gained on placental oxygen and nutrient transfer and utilization from use of pregnant sheep, often confirmed in the human once appropriate technologies became available. This review will focus on one sheep model, used to examine the impact of placental insufficiency-induced IUGR on oxygen and nutrient transport and utilization. |
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Authors:
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James S Barry; Paul J Rozance; Russell V Anthony |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 32 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-16 Completed Date: 2008-09-30 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 225-30 Citation Subset: IM |
Affiliation:
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Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. James.Barry@UCHSC.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / metabolism, physiopathology* Blood Glucose / metabolism Disease Models, Animal* Female Fetal Growth Retardation / etiology, metabolism* Humans Insulin / secretion Maternal Nutritional Physiological Phenomena / physiology Oxygen / metabolism Placental Circulation / physiology* Placental Insufficiency / metabolism, physiopathology* Pregnancy Regional Blood Flow Sheep / metabolism, physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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