Document Detail

An animal model of placental insufficiency-induced intrauterine growth restriction.
MedLine Citation:
PMID:  18482626     Owner:  NLM     Status:  MEDLINE    
Intrauterine growth restriction (IUGR), often associated with functional placental insufficiency, results in increased perinatal mortality and morbidity. For obvious reasons, many questions regarding the progression of IUGR pregnancies cannot be addressed experimentally in humans, predicating the use of animal models. Although no animal model fully recapitulates human pregnancy, the pregnant sheep has been used extensively to investigate maternal-fetal interactions. In sheep, surgical placement of catheters in both the maternal and fetal vasculature allows repeated sampling from nonanesthetized pregnancies. Considerable insight has been gained on placental oxygen and nutrient transfer and utilization from use of pregnant sheep, often confirmed in the human once appropriate technologies became available. This review will focus on one sheep model, used to examine the impact of placental insufficiency-induced IUGR on oxygen and nutrient transport and utilization.
James S Barry; Paul J Rozance; Russell V Anthony
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  32     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-16     Completed Date:  2008-09-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-30     Citation Subset:  IM    
Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.
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MeSH Terms
Anoxia / metabolism,  physiopathology*
Blood Glucose / metabolism
Disease Models, Animal*
Fetal Growth Retardation / etiology,  metabolism*
Insulin / secretion
Maternal Nutritional Physiological Phenomena / physiology
Oxygen / metabolism
Placental Circulation / physiology*
Placental Insufficiency / metabolism,  physiopathology*
Regional Blood Flow
Sheep / metabolism,  physiology
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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