| An animal model of non-obstructive bladder instability. | |
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MedLine Citation:
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PMID: 2342196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight minipigs with proven normal bladder function have undergone a circumferential supratrigonal bladder transection. Urodynamic studies were performed before, and at various times up to eight months after operation. Over the same period biopsies were taken for physiological and histological studies. By three weeks after transection all animals had developed bladder instability, the abnormal contractions being maintained for the duration of the study. Concomitant with this change was the development, in vitro, of a non-specific detrusor smooth muscle supersensitivity similar to that which occurs in obstructed animals. By contrast with the latter group there was, however, no loss of cholinergic nerve from the transected bladder muscle. The transected (decentralised) minipig may be a useful model for the study of bladder instability not associated with outflow obstruction. The findings suggest that anatomical denervation is not a prerequisite for unstable contractions although a functional loss of nerve may be of importance. Supersensitivity, however, appears to occur in both obstructed and nonobstructed instability. |
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Authors:
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K K Sethia; A F Brading; J C Smith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of urology Volume: 143 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1990 Jun |
Date Detail:
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Created Date: 1990-06-28 Completed Date: 1990-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1243-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, Oxford, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Denervation / methods Female Male Muscle Contraction / physiology Muscle, Smooth / physiopathology Swine Swine, Miniature Urinary Bladder / innervation*, physiopathology Urinary Bladder, Neurogenic / etiology*, physiopathology Urodynamics / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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