Document Detail

An animal model of non-obstructive bladder instability.
MedLine Citation:
PMID:  2342196     Owner:  NLM     Status:  MEDLINE    
Eight minipigs with proven normal bladder function have undergone a circumferential supratrigonal bladder transection. Urodynamic studies were performed before, and at various times up to eight months after operation. Over the same period biopsies were taken for physiological and histological studies. By three weeks after transection all animals had developed bladder instability, the abnormal contractions being maintained for the duration of the study. Concomitant with this change was the development, in vitro, of a non-specific detrusor smooth muscle supersensitivity similar to that which occurs in obstructed animals. By contrast with the latter group there was, however, no loss of cholinergic nerve from the transected bladder muscle. The transected (decentralised) minipig may be a useful model for the study of bladder instability not associated with outflow obstruction. The findings suggest that anatomical denervation is not a prerequisite for unstable contractions although a functional loss of nerve may be of importance. Supersensitivity, however, appears to occur in both obstructed and nonobstructed instability.
K K Sethia; A F Brading; J C Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  143     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-06-28     Completed Date:  1990-06-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1243-6     Citation Subset:  AIM; IM    
Department of Urology, Oxford, United Kingdom.
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MeSH Terms
Denervation / methods
Muscle Contraction / physiology
Muscle, Smooth / physiopathology
Swine, Miniature
Urinary Bladder / innervation*,  physiopathology
Urinary Bladder, Neurogenic / etiology*,  physiopathology
Urodynamics / physiology

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