| An animal model of chronic ischemic neuropathy with proliferative changes of nerve microvessel wall. | |
| | |
MedLine Citation:
|
PMID: 8289080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to produce a model of ischemic neuropathy with neural microvascular alterations, sodium laurate was injected into a femoral artery and saline into the contralateral artery at the mid-thigh level in Sprague-Dawley rats aged 11 weeks. In view of the dose-related findings, 0.3 mg sodium laurate dissolved in 0.1 ml saline was used for the main experiment. The laurate-injected leg showed paresis during the experimental period. On day 1-7, various stages of Wallerian degeneration and acute microvascular changes were found. At 1 month, regenerating myelinated nerve fibers (MNFs) were found at the central or total fascicular area mainly in the distal tibial nerve. Morphometric analyses suggested that MNFs other than regenerating fibers are atrophic ones. The proliferative changes of nutrient microvascular walls were striking. The percent of closed epineurial microvessels was significantly larger on the laurate-injected sides and inversely associated with the diameter of MNFs. At 7 months, the attenuation of MNFs was more prominent and microvascular alterations were persistently observed. These pathological findings resemble those of chronic ischemic neuropathy including diabetic neuropathy, suggesting that this neuropathy model might provide some valuable and useful clues for clarifying the pathogenesis of chronic ischemic neuropathy. |
| | |
Authors:
|
H Yasuda; T Hisanaga; K Maeda; T Kawabata; T Takigawa; M Terada; R Kikkawa; Y Shigeta |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the neurological sciences Volume: 120 ISSN: 0022-510X ISO Abbreviation: J. Neurol. Sci. Publication Date: 1993 Dec |
Date Detail:
|
Created Date: 1994-02-22 Completed Date: 1994-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 64-70 Citation Subset: IM |
Affiliation:
|
Third Department of Medicine, Shiga University of Medical Science, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arterioles / pathology Disease Models, Animal Femoral Artery / pathology* Ischemia / pathology*, physiopathology* Lauric Acids Male Microcirculation / pathology* Nerve Fibers, Myelinated / pathology, ultrastructure Nerve Regeneration Rats Rats, Sprague-Dawley Sciatic Nerve / blood supply*, pathology, physiopathology Tibial Nerve / blood supply*, pathology, physiopathology Time Factors Wallerian Degeneration |
| Chemical | |
Reg. No./Substance:
|
0/Lauric Acids; 143-07-7/lauric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: On the possibility of autolysosomal processing of skein-like inclusions. Electron microscopic observ...
Next Document: Muscular weakness in the mdx mouse.