Document Detail

An animal model assessment of common dye-induced allergic contact dermatitis.
MedLine Citation:
PMID:  17598023     Owner:  NLM     Status:  MEDLINE    
Dyes are a category of substances capable of inducing allergic contact dermatitis found in a variety of foods, drugs, textiles, cosmetics, and hair dyes. This study tested 33 dyes in guinea pigs using a modified Buehler and Klecak method for open epicutaneous testing. The dyes were tested at an induction concentration of 10% and challenge concentrations of 10.0%, 5.0%, and 2.5%. Nine of the 33 dyes tested produced positive allergic reactions in the guinea pig model (2-amino-4-nitrophenol, 2-amino-5-nitrophenol, acid yellow 23, acid orange 3, basic black 3, basic orange 1, disperse orange 3, solvent black 27, and solvent black 34). When eight of the nine positive dyes were retested using a 1% induction concentration, five dyes produced allergic contact dermatitis at a 1% challenge concentration (2-amino-4-nitrophenol, 2-amino-5-nitrophenol, acid yellow 23, disperse orange 3, and solvent black 34), two at a 0.5% challenge concentration (2-amino-5-nitrophenol and solvent black 34), and one at a 0.25% challenge concentration (2-amino-5-nitrophenol). DNCB at a 0.5% induction/challenge concentration was used as a positive control. With the exception of disperse orange 3 and acid yellow 23, the seven additional dyes that elicited positive allergic reactions in the guinea pig model have not been previously reported.
Joe Dinardo; Zoe Diana Draelos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cosmetic science     Volume:  58     ISSN:  1525-7886     ISO Abbreviation:  J Cosmet Sci     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-06-28     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814276     Medline TA:  J Cosmet Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
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MeSH Terms
Allergens / adverse effects*
Coloring Agents / adverse effects*
Dermatitis, Allergic Contact / diagnosis*,  etiology,  pathology
Disease Models, Animal
Guinea Pigs
Skin Tests
Reg. No./Substance:
0/Allergens; 0/Coloring Agents

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