| The angiotensin-converting enzyme inhibitor, perindopril, prevents cardiac hypertrophy in low-renin hypertensive rats. | |
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MedLine Citation:
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PMID: 8467569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. To examine whether an angiotensin-converting enzyme (ACE) inhibitor prevents left ventricular (LV) hypertrophy even in low-renin hypertension, we studied the effect of the administration of perindopril on cardiac hypertrophy induced by partial renal ablation in hypertensive rats. 2. Rats that had undergone partial nephrectomy were randomly divided into four groups that received the following as drinking water: Group A, tap water; Group B, 1% sodium chloride (NaCl); Group C, NaCl + perindopril 3 mg/kg per day; and Group D, NaCl + perindopril 1 mg/kg per day. Plasma renin activity (PRA), angiotensin-II (AII) concentration and cardiac tissue AII were measured. 3. Supplementation of NaCl following nephrectomy increased the blood pressure and cardiac weight compared with rats that had undergone nephrectomy alone (P < 0.05). Treatment with perindopril (3 mg/kg per day) did not affect the blood pressure and plasma AII but inhibited the increase of cardiac weight (P < 0.05). Left ventricular AII was decreased in cases of reduced renal mass hypertension, but was not changed by treatment with perindopril. 4. These results demonstrate that perindopril may be able to prevent LV hypertrophy even in low-renin hypertension, which was not mediated by a reduction of blood pressure or suppression of the circulating and cardiac renin-angiotensin systems. Other mechanisms of ACE inhibitors may contribute to the cardioprotective effects. |
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Authors:
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F Nakamura; M Nagano; J Higaki; K Higashimori; R Morishita; H Mikami; T Ogihara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 20 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-05-07 Completed Date: 1993-05-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 135-40 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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blood,
metabolism Angiotensin-Converting Enzyme Inhibitors / therapeutic use* Animals Blood Pressure / physiology Body Weight / physiology Heart Rate / physiology Hypertension, Renal / chemically induced, complications* Hypertrophy, Left Ventricular / etiology, pathology, prevention & control* Indoles / therapeutic use* Male Myocardium / metabolism Nephrectomy Organ Size / physiology Perindopril Radioimmunoassay Rats Rats, Wistar Renin / blood, deficiency* Sodium Chloride |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 11128-99-7/Angiotensin II; 7647-14-5/Sodium Chloride; 82834-16-0/Perindopril; EC 3.4.23.15/Renin |
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