| The angiogenic effect of tissue factor on tumors and wounds. | |
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MedLine Citation:
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PMID: 9701449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a novel function of tissue factor (TF) as an angiogenic factor in malignant and non-malignant cells and tissue. When methylcholanthrene A-induced murine fibrosarcoma (Meth-A sarcoma) was stably transfected with mouse TF (mTF) cDNA (pXT1 expression vector), its vascularization in vivo was significantly enhanced, whereas TF-antisense suppressed the vascularization and tumor growth. In vitro expression of vascular endothelial growth factor (VEGF) was enhanced with stable transfection of mTF (pcDNA3 expression vector) into a mouse fibroblast cell line (NIH3T3). Moreover, in vivo topical transfection of mTF (pcDNA3) showed an enhanced vascularization and healing in a diabetic mouse wound-healing model. This effect of TF as an angiogenic factor might be useful as an antitumor therapy against hypervascular tumors or as a novel agent against delayed wound healing. |
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Authors:
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K Nakagawa; Y Zhang; H Tsuji; M Yoshizumi; T Kasahara; H Nishimura; P P Nawroth; M Nakagawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Seminars in thrombosis and hemostasis Volume: 24 ISSN: 0094-6176 ISO Abbreviation: Semin. Thromb. Hemost. Publication Date: 1998 |
Date Detail:
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Created Date: 1998-11-12 Completed Date: 1998-11-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0431155 Medline TA: Semin Thromb Hemost Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 207-10 Citation Subset: IM |
Affiliation:
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Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3T3 Cells Animals Endothelial Growth Factors / physiology Fibrosarcoma / blood supply*, genetics Lymphokines / physiology Mice Mice, Inbred NOD Neoplasms, Experimental / blood supply*, genetics Neovascularization, Pathologic* Thromboplastin / physiology* Transfection Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Wound Healing* |
| Chemical | |
Reg. No./Substance:
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0/Endothelial Growth Factors; 0/Lymphokines; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 9035-58-9/Thromboplastin |
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