Document Detail

The angiogenesis marker ED-B+ fibronectin isoform in intracranial meningiomas.
MedLine Citation:
PMID:  10819258     Owner:  NLM     Status:  MEDLINE    
Fibronectins (FNs), adhesive glycoproteins mainly expressed in the extracellular matrix, are polymorphic molecules whose various isoforms are dependent on alternative splicing patterns. The isoform containing the ED-B sequence and occurring in foetal and neoplastic tissues (oncofoetal or B+FN) has been previously recognized as a marker for angiogenesis. The distribution of this isoform was analyzed in a consecutive series of 134 surgically obtained intracranial meningiomas, using specific monoclonal antibodies. Oncofoetal FN was found to be widely distributed in the vessels of anaplastic meningiomas, with its expression being restricted in the vasculature of the typical subtypes. and absent in the neighbouring cerebral tissue. The ubiquitous vascular expression of B+FN in meningiomatous malignancies might provide a potential target for the in vivo delivery of angiosuppressive agents.
P Castellani; A Dorcaratto; A Pau; M Nicola; A Siri; B Gasparetto; L Zardi; G Viale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurochirurgica     Volume:  142     ISSN:  0001-6268     ISO Abbreviation:  Acta Neurochir (Wien)     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-24     Completed Date:  2000-07-24     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0151000     Medline TA:  Acta Neurochir (Wien)     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  277-82     Citation Subset:  IM    
DI.S.C.A.T Department of Surgery, University of Genoa Medical School, Italy.
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MeSH Terms
Capillaries / pathology
Fibronectins / analysis*
Immunoenzyme Techniques
Meningeal Neoplasms / blood supply*,  pathology
Meninges / blood supply,  pathology
Meningioma / blood supply*,  pathology
Neovascularization, Pathologic / pathology*
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Fibronectins; 0/Tumor Markers, Biological; 0/oncofetal fibronectin

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