Document Detail


The anemia of sarcoidosis.
MedLine Citation:
PMID:  3381019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anemia and leukopenia have been reported in sarcoidosis. In order to characterize the prevalence and association with disease activity, 75 patients with active pulmonary sarcoidosis were studied. One or more hematologic abnormalities were identified in 87% of patients studied. Anemia was present in 21 patients (28%), and bone marrow examination in 17 anemic patients revealed noncaseating granulomas in 9 patients and absent iron stores in 8 patients. The bone marrow aspirates did not show characteristics seen in other anemias of chronic disease, such as tuberculosis. In the majority of unexplained anemia cases, hemoglobin levels normalized with prednisone treatment. Forty-one of 75 patients (55%) had lymphopenia. Anemia found in patients with active sarcoidosis was associated with noncaseating granulomas in the bone marrow and an improvement with steroid therapy.
Authors:
E E Lower; J T Smith; O J Martelo; R P Baughman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Sarcoidosis     Volume:  5     ISSN:  0393-1447     ISO Abbreviation:  Sarcoidosis     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-07-19     Completed Date:  1988-07-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8500778     Medline TA:  Sarcoidosis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Cincinnati Medical Center, OH.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / etiology*
Bone Marrow / pathology
Female
Granuloma / pathology
Humans
Iron / blood
Leukopenia / etiology
Lung Diseases / blood,  complications*,  drug therapy
Male
Prednisone / therapeutic use
Sarcoidosis / blood,  complications*,  drug therapy
Grant Support
ID/Acronym/Agency:
RR-00068/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
53-03-2/Prednisone; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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