Document Detail

The anatomy of the late radiation encephalopathy.
MedLine Citation:
PMID:  1193095     Owner:  NLM     Status:  MEDLINE    
The clinico-pathological data and the topography of the lesions were determined in 13 cases of late radiation encephalopathy. In one case the arterial vascularisation was studied by the translucidation technique after filling of the blood vessels with a colloidal barium sulphate solution. The radiation lesions consisted of areas of focal necrosis and of diffuse demyelination and necrosis of the deep cerebral structures and the brain stem. Demyelination was predominantly present in cases of late appearance of the neurological symptoms while necrosis was found in cases with a short latency period. The cerebral cortex and the arcuate fibres were always the most preserved structures. The topography of the focal lesions in the cerebral hemispheres and in the brain stem corresponded well to the vascular supply areas of the deep perforating arteries, while the diffuse lesions always had a predominant distribution in the periventricular arterial end- and border-zones. These observations were also confirmed by a post mortem angiographic study. The present report argues once more for a vascular aetiology as cause of the late radiation encephalopathy.
J De Reuck; H vander Eecken
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European neurology     Volume:  13     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-26     Completed Date:  1976-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  481-94     Citation Subset:  IM    
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MeSH Terms
Brain / pathology,  radiation effects*
Brain Diseases / etiology*,  pathology
Brain Stem / pathology,  radiation effects
Cerebral Arteries / pathology
Cerebrovascular Circulation
Child, Preschool
Demyelinating Diseases / pathology
Middle Aged
Radiation Injuries*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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