Document Detail

The anatomy of the human genome: a neo-Vesalian basis for medicine in the 21st century.
MedLine Citation:
PMID:  11710895     Owner:  NLM     Status:  MEDLINE    
Since 1956, the anatomy of the human genome has been described on the basis of chromosome studies, gene mapping, and DNA sequencing. The gross anatomy of Andreas Vesalius, published in 1543, played a leading role in the development of modern medicine. The objective of this article is to show that knowledge of genomic anatomy is having a comparably strong and pervasive influence on all of medicine. The research revealing human genome anatomy is reviewed. The insight provided by genome anatomy has brought about shifts of focus, both in research and in the clinic, eg, from genomics to proteomic and from the individually rare, single-gene disorders to common disorders. Genomic anatomy permits medicine to become more predictive and preventive. At the same time, diagnosis and treatment are rendered more sensitive, specific, effective, and safe. Hazards in misuse and misunderstanding of the information exist. Education of both the public and health professionals is vital if the full benefits of neo-Vesalian medicine are to be realized.
V A McKusick
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  JAMA     Volume:  286     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-16     Completed Date:  2001-12-28     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2289-95     Citation Subset:  AIM; IM    
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MeSH Terms
Chromosome Mapping / history
Cytogenetics / history
Genetics, Medical / history*,  trends
History, 20th Century
History, 21st Century
Human Genome Project / history
Sequence Analysis, DNA / history

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