| The anatomical basis of complete atrioventricular block in cats with hypertrophic cardiomyopathy. | |
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MedLine Citation:
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PMID: 16844442 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cardiac conduction system was examined histologically in 13 feline cases of hypertrophic cardiomyopathy (HCM) with complete atrioventricular (AV) block. Marked degeneration and fibrous replacement of the AV conduction system were consistently observed in the combined regions of the branching portion of the AV bundle and the upper portion of the left bundle branch. These changes were associated with extensive fibrosis of the central fibrous body and endocardial and myocardial fibrosis in the upper border of the ventricular septum. Chondrometaplastic lesions or osseous lesions, or both, present in the base of the central fibrous body, compressed the underlying penetrating or branching (or both) portions of the AV bundle, causing apparent reduction of the conduction fibres. The pathological process and the nature and predilection sites of the lesions resembled those associated with ageing in human patients with complete AV block. It is possible that the pathological process in the cats was fundamentally related to the normal ageing phenomenon and may have been exacerbated by mechanical forces created by the cardiac hypertrophy associated with HCM. |
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Authors:
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T Kaneshige; N Machida; H Itoh; Y Yamane |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of comparative pathology Volume: 135 ISSN: 0021-9975 ISO Abbreviation: J. Comp. Pathol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-17 Completed Date: 2006-10-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0102444 Medline TA: J Comp Pathol Country: England |
Other Details:
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Languages: eng Pagination: 25-31 Citation Subset: IM |
Affiliation:
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Department of Veterinary Surgery, Tokyo University of Agriculture and Technology, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bundle of His / pathology Cardiomyopathy, Hypertrophic / pathology*, veterinary Cats Electrocardiography / veterinary Fibrosis / pathology, veterinary Heart Block / diagnosis, pathology*, veterinary Heart Conduction System / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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