| The anaphase-promoting complex is required in both dividing and quiescent cells during zebrafish development. | |
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MedLine Citation:
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PMID: 17141209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The anaphase-promoting complex/cyclosome (APC/C) regulates multiple stages of the cell cycle, most prominently mitosis. We describe zebrafish with mutations in two APC/C subunits, Cdc16 and Cdc26, whose phenotypes reveal a multifaceted set of defects resulting from the gradual depletion of the APC/C. First, loss of the APC/C in dividing cells results in mitotic arrest, followed by apoptosis. This defect becomes detectable in different organs at different larval ages, because the subunits of the APC/C are maternally deposited, are unusually stable, and are depleted at uneven rates in different tissues. Second, loss of the APC/C in quiescent or differentiated cells results in improper re-entry into the cell cycle, again in an apparently tissue-specific manner. This study is the first demonstration of both functions of the APC/C in a vertebrate organism and also provides an illustration of the surprisingly complex effects that essential, maternally supplied factors can have on the growing animal over a period of 10 days or longer. |
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Authors:
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Ann M Wehman; Wendy Staub; Herwig Baier |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-11-03 |
Journal Detail:
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Title: Developmental biology Volume: 303 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-19 Completed Date: 2007-04-09 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 144-56 Citation Subset: IM |
Affiliation:
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Programs in Genetics and Developmental Biology, University of California-San Francisco, 1550 4th Street, San Francisco, CA 94158-2722, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cell Cycle / physiology* Cell Cycle Proteins / genetics Chromosome Mapping Cyclin B DNA Primers Immunohistochemistry Mitosis / physiology* Models, Biological* Molecular Sequence Data Retina / embryology Sequence Analysis, DNA Ubiquitin-Protein Ligase Complexes / genetics*, metabolism* Zebrafish / embryology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EY 13855/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Cyclin B; 0/DNA Primers; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
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