| The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions. | |
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MedLine Citation:
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PMID: 20074037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The APC/C (anaphase-promoting complex/cyclosome) is an E3 ubiquitin ligase that targets specific substrates for degradation by the 26S proteasome. APC/C activity depends on two cofactors, namely Cdc20 (cell division cycle 20) and Cdh1, which select the appropriate targets for ubiquitination. It is well established that APC/C is a target of the SAC (spindle assembly checkpoint) during mitosis and has critical roles in controlling the protein levels of major regulators of mitosis and DNA replication. In addition, recent studies have suggested new cell-cycle-independent functions of APC/C in non-mitotic cells and specifically in neuronal structure and function. Given the relevant functions of APC/C in cell proliferation and neuronal physiology, modulating APC/C activity may have beneficial effects in the clinic. |
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Authors:
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Eusebio Manchado; Manuel Eguren; Marcos Malumbres |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemical Society transactions Volume: 38 ISSN: 1470-8752 ISO Abbreviation: Biochem. Soc. Trans. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-15 Completed Date: 2010-03-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506897 Medline TA: Biochem Soc Trans Country: England |
Other Details:
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Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
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Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncol?gicas, Melchor Fern?ndez Almagro 3, E-28029 Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cadherins / metabolism Cell Cycle / physiology* Cell Cycle Proteins / metabolism Cyclin-Dependent Kinases / metabolism Humans Mitotic Spindle Apparatus / metabolism Neurons / cytology, physiology Proteasome Endopeptidase Complex / metabolism Ubiquitin-Protein Ligase Complexes / physiology* |
| Chemical | |
Reg. No./Substance:
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0/CDH1 protein, human; 0/Cadherins; 0/Cell Cycle Proteins; 156288-95-8/CDC20 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinases; EC 3.4.25.1/Proteasome Endopeptidase Complex; EC 3.4.99.-/ATP dependent 26S protease; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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