Document Detail


An analysis of trends and growth factor receptor expression of GI carcinoid tumors.
MedLine Citation:
PMID:  19582519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The purpose of our study was twofold: (1) to determine the incidence, patient and tumor characteristics, and outcome of patients with gastrointestinal carcinoid tumors using the Surveillance, Epidemiology and End Results (SEER) database, and (2) to delineate the expression pattern of growth factor receptors (GFRs) in carcinoid tumors.
MATERIALS AND METHODS: The SEER database search provided information on patients diagnosed with carcinoid tumors from 1990 to 2002. Carcinoid tumor sections (n = 46) were stained for the GFRs: epidermal growth factor receptor, insulin-like growth factor receptor (IGFR), vascular endothelial growth factor receptor (VEGFR), and HER-2/neu.
RESULTS: Over the 12-year analysis period, 18,180 patients were identified with carcinoid tumors of the foregut, midgut, and hindgut; the incidence of carcinoid tumors increased approximately 2-fold during this time period. Of the patients with carcinoid tumors, there was a trend of increased expression of VEGFR and IGFR, particularly in the foregut and midgut carcinoids. Analysis of the SEER database confirms that the incidence of carcinoid tumors is increasing with an approximate doubling in the number of carcinoid cases from 1990 to 2002. Furthermore, an increase in VEGFR and IGFR expression suggests that GFR inhibitors may be effective adjuvant therapy for carcinoid cancer.
Authors:
Kanika A Bowen; Scott R Silva; Jessica N Johnson; Hung Q Doan; Lindsey N Jackson; Pat Gulhati; Suimin Qiu; Taylor S Riall; B Mark Evers
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-07-07
Journal Detail:
Title:  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract     Volume:  13     ISSN:  1873-4626     ISO Abbreviation:  J. Gastrointest. Surg.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-08     Completed Date:  2010-01-05     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9706084     Medline TA:  J Gastrointest Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1773-80     Citation Subset:  IM    
Affiliation:
Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoid Tumor / metabolism*
Female
Gastrointestinal Neoplasms / epidemiology,  metabolism*
Humans
Incidence
Male
Middle Aged
Receptors, Growth Factor / metabolism*
SEER Program
Grant Support
ID/Acronym/Agency:
P01 DK035608-230001/DK/NIDDK NIH HHS; P01 DK035608-239004/DK/NIDDK NIH HHS; P01DK35608/DK/NIDDK NIH HHS; R01 CA104748/CA/NCI NIH HHS; R01 CA104748-05/CA/NCI NIH HHS; R01 CA125454/CA/NCI NIH HHS; R01 CA125454/CA/NCI NIH HHS; R01 CA125454-02/CA/NCI NIH HHS; R01 DK048498-14/DK/NIDDK NIH HHS; R01 DK48498/DK/NIDDK NIH HHS; T32 DK007639/DK/NIDDK NIH HHS; T32 DK007639-17/DK/NIDDK NIH HHS; T32DK07639/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Growth Factor
Comments/Corrections

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