Document Detail

An analysis of six patients with Parkinson's disease who have been unresponsive to L-dopa therapy.
MedLine Citation:
PMID:  4714098     Owner:  NLM     Status:  MEDLINE    
Six patients diagnosed as Parkinson's disease on a clinical basis alone are described, and their response to L-dopa and to alpha methyl dopa hydrazine (MK 486) and L-dopa. They are compared with 239 other patients with Parkinson's disease treated in the same time period. These six patients were unusual in that they did not have a clinical response to L-dopa, nor did they develop dyskinesias on L-dopa or on L-dopa with MK 486, although they showed high blood levels of L-dopa and high homovanillic acid levels in the spinal fluid. Unresponsiveness to L-dopa is attributed to a specific brain mechanism and not to problems of transport of L-dopa to the brain or to abnormal peripheral metabolism of L-dopa. The term `motor unresponsiveness to L-dopa' may be useful to describe such patients who may eventually be shown to be suffering from diseases other than Parkinsonism.
R J Mones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  36     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1973 Jun 
Date Detail:
Created Date:  1973-08-28     Completed Date:  1973-08-28     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  362-7     Citation Subset:  IM    
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MeSH Terms
Carbidopa / administration & dosage,  therapeutic use
Diagnosis, Differential
Dihydroxyphenylalanine / administration & dosage,  blood,  therapeutic use*
Evaluation Studies as Topic
Homovanillic Acid / cerebrospinal fluid
Hydrazines / therapeutic use*
Muscle Rigidity / drug therapy
Muscles / drug effects
Neurologic Examination
Parkinson Disease / blood,  cerebrospinal fluid,  diagnosis,  drug therapy*
Tremor / drug therapy
Reg. No./Substance:
0/Hydrazines; 306-08-1/Homovanillic Acid; 38821-49-7/Carbidopa; 63-84-3/Dihydroxyphenylalanine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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